Two new sesquiterpenoids from Wenyujin Rhizoma Concisum.
10.19540/j.cnki.cjcmm.20250131.201
- Author:
Yu LI
1
;
Min CHEN
1
;
Cheng ZHU
1
;
Ci-Mei WU
1
;
Chao-Jie WANG
2
;
Jian-Yong DONG
1
Author Information
1. School of Chinese Medicine, Wenzhou Medical University Wenzhou 325035, China.
2. School of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China.
- Publication Type:Journal Article
- Keywords:
Wenyujin Rhizoma Concisum;
anti-angiogenesis;
sesquiterpenoids
- MeSH:
Sesquiterpenes/isolation & purification*;
Humans;
Drugs, Chinese Herbal/isolation & purification*;
Rhizome/chemistry*;
Human Umbilical Vein Endothelial Cells/drug effects*;
Molecular Structure;
Cell Proliferation/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(10):2704-2710
- CountryChina
- Language:Chinese
-
Abstract:
This study explored the active ingredients for anti-angiogenesis in Wenyujin Rhizoma Concisum. Ten sesquiterpenoids were isolated from Wenyujin Rhizoma Concisum by silica gel column chromatography, thin layer chromatography, and high performance liquid chromatography. According to the results of multiple spectroscopic methods and circular dichroism, they were identified as wenyujinlactam A(1),(4S,7S)11-hydroxycurdione(2), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide(3), curcumadione(4), phaeocaulisin E(5), procurcumadiol(6), zedouronediol(7), epiprocurcumenol(8), gajutsulactone A(9), and(7Z)-1β,4α-dihydroxy-5α,8β(H)-eudesm-7(11)-en-8,12-olide(10). Compounds 1 and 2 were new sesquiterpenoids. Compounds 1, 6, 8, and 10 can inhibit human umbilical vein endothelial cells(HUVEC) proliferation with IC_(50) values of 38.83, 45.19, 32.12, and 37.80 μmol·L~(-1), respectively. Compounds 1 and 10 can inhibit HUVEC migration with IC_(50) values of 29.70 and 36.48 μmol·L~(-1), respectively.
