Standardization of refining process of Hongsheng Dan and change law of substances.
10.19540/j.cnki.cjcmm.20250313.304
- Author:
Jing-Jing YANG
1
;
Qing-Xia GAN
1
;
Yu YANG
1
;
Hou-Bo ZHOU
1
;
Can LIU
1
;
Jin WANG
2
;
Qin-Wan HUANG
1
Author Information
1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
2. School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
- Publication Type:Journal Article
- Keywords:
Hongsheng Dan;
X-ray diffraction(XRD);
atomic absorption spectrophotometry(AAS);
differential scanning calorimetry(DSC);
infrared thermal imaging;
refining process
- MeSH:
Drugs, Chinese Herbal/standards*;
Temperature
- From:
China Journal of Chinese Materia Medica
2025;50(10):2695-2703
- CountryChina
- Language:Chinese
-
Abstract:
Hongsheng Dan, historically referred to as the "surgical sacred medicine", is at risk of losing its refining technology in contemporary times. This study aimed to preserve and innovate this traditional non-heritage refining technology. By utilizing the analytic hierarchy process(AHP) combined with the entropy weight method, this study established the hierarchical structure model of refining process of Hongsheng Dan and conducted a single factor experiment and an L_9(3~4) orthogonal experiment to optimize the refining method of Hongsheng Dan. Additionally, the study employed infrared thermal imaging to monitor temperature variations of Hongsheng Dan during the refining process. The optimized refining parameters for Hongsheng Dan were established as follows: a slow fire temperature of 175 ℃ with a duration of 30 minutes, a strong fire temperature of 270 ℃ with a duration of 60 minutes, and a tail fire temperature of 180 ℃ with a duration of 15 minutes. The stability and feasibility of this optimized process were confirmed through validation tests. The research focused on the material transformation of Hongsheng Dan, starting from the material changes during the refining process of Hongsheng Dan and the synthesis of mercuric oxide from nitric acid. The study investigated elemental transformations, physical phase changes, and alterations in thermal properties. 78.98% of the mercury in Hongsheng Dan and 80.21% of the mercury in mercuric oxide from nitric acid were retained. The diffraction peak intensity of the(011) crystal plane of Hongsheng Dan was highest at approximately 30.07°, indicating that the(011) crystal plane had a preferred crystalline orientation. Furthermore, the temperature range for the alteration in thermal properties during the refining process of Hongsheng Dan was found to be between 80 ℃ and 130 ℃. This research not only optimized the refining technology of Hongsheng Dan but also pioneered the application of infrared thermal imaging to study temperature changes throughout the refining process. By exploring the material transformation patterns of Hongsheng Dan and the synthesis of mercuric oxide from nitric acid, the study provided technical support for the preservation and innovation of Hongsheng Dan.
