Application of motor behavior evaluation method of zebrafish model in traditional Chinese medicine research.
10.19540/j.cnki.cjcmm.20250103.701
- Author:
Xin LI
1
;
Qin-Qin LIANG
1
;
Bing-Yue ZHANG
1
;
Zhong-Shang XIA
2
;
Gang BAI
3
;
Zheng-Cai DU
2
;
Er-Wei HAO
2
;
Jia-Gang DENG
2
;
Xiao-Tao HOU
1
Author Information
1. School of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine,Guangxi University Engineering Research Center of Reutilization of Traditional Chinese Medicine Resources,Guangxi Key Laboratory of Traditional Chinese Medicine Formulas Theory and Transformation for Damp Disease Nanning 530200, China.
2. Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine,Guangxi University Engineering Research Center of Reutilization of Traditional Chinese Medicine Resources,Guangxi Key Laboratory of Traditional Chinese Medicine Formulas Theory and Transformation for Damp Disease Nanning 530200, China.
3. State Key Laboratory of Medicinal Chemical Biology,School of Pharmacy, Nankai University Tianjin 300353, China.
- Publication Type:English Abstract
- Keywords:
anti-epilepsy;
anti-fatigue;
motor behavior;
traditional Chinese medicine;
zebrafish
- MeSH:
Zebrafish/physiology*;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/therapeutic use*;
Disease Models, Animal;
Drug Evaluation, Preclinical/methods*;
Animals;
Sleep Wake Disorders/physiopathology*;
Epilepsy/physiopathology*;
Neurodegenerative Diseases/physiopathology*;
Fatigue/physiopathology*;
Behavior, Animal/physiology*;
Motor Activity/physiology*
- From:
China Journal of Chinese Materia Medica
2025;50(10):2631-2639
- CountryChina
- Language:Chinese
-
Abstract:
The zebrafish model has attracted much attention due to its strong reproductive ability, short research cycle, and ease of maintenance. It has always been an important vertebrate model system, often used to carry out human disease research. Its motor behavior features have the advantages of being simpler, more intuitive, and quantifiable. In recent years, it has received widespread attention in the study of traditional Chinese medicine(TCM)for the treatment of sleep disorders, neurodegenerative diseases, fatigue, epilepsy, and other diseases. This paper reviews the characteristics of zebrafish motor behavior and its applications in the pharmacodynamic verification and mechanism research of TCM extracts, active ingredients, and TCM compounds, as well as in active ingredient screening and safety evaluation. The paper also analyzes its advantages and disadvantages, with the aim of improving the breadth and depth of zebrafish and its motor behavior applications in the field of TCM research.
