Role of miRNA in prostate cancer and research progress of traditional Chinese medicine intervention.
10.19540/j.cnki.cjcmm.20250120.501
- Author:
Sheng-Long LI
1
;
Yong-Lin LIANG
2
;
Xiu-Juan YANG
2
;
Yong-Qiang ZHAO
3
;
Hui LI
1
;
Gang-Gang LU
1
;
Xu MA
1
;
Da-Cheng TIAN
1
Author Information
1. College of Integrative Chinese and Western Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China.
2. School of Basic Medical Sciences, Gansu University of Chinese Medicine Lanzhou 730000, China.
3. Urology Department, Gansu Provincial Hospital of Traditional Chinese Medicine Lanzhou 730050, China.
- Publication Type:English Abstract
- Keywords:
miRNA;
prostate cancer;
research progress;
traditional Chinese medicine
- MeSH:
Humans;
MicroRNAs/metabolism*;
Prostatic Neoplasms/metabolism*;
Male;
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional;
Animals;
Gene Expression Regulation, Neoplastic/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(10):2619-2630
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer(PCa) is a common malignant tumor among elderly men, with high incidence and mortality rates worldwide, posing a serious threat to human health. Traditional treatments face limitations, highlighting the urgent need for novel therapeutic strategies. Recent studies on the regulatory mechanisms of micro ribonucleic acid(microRNA, miRNA) in tumor development has identified miRNA as new targets for PCa diagnosis and treatment. Traditional Chinese medicine(TCM), with its multi-mechanism, multi-target, and multi-pathway regulatory properties, shows promising potential in miRNA-based PCa therapy. This review summarized recent findings on miRNA' roles in PCa and research progress of TCM intervention and found that a variety of miRNA played important regulatory roles in cell differentiation, proliferation, apoptosis, invasion, metastasis, immune microenvironment, and drug resistance, and their potential as biomarkers for PCa diagnosis, prognosis, and therapy, indicating the potential to be a biomarker for the diagnosis, prognosis evaluation, and treatment of PCa. The review concluded that the active components of TCM(terpenoids, flavonoids, alkaloids, and others) and compounds(Yishen Tonglong Decoction, Shenhu Decoction, Zhoushi Qiling Decoction, Fuzheng Yiliu Decoction, and Qilan Formula) could regulate the expression of their downstream target genes by acting on specific miRNA and affect the above biological behaviors of PCa cells, thus playing a role in the treatment of PCa. This review aims to provide a theoretical basis for miRNA as potential biomarkers and therapeutic targets for PCa and suggest new avenues for further development of targeted therapy strategies against miRNA.
