Mechanisms and treatment of inflammation-cancer transformation in colon from perspective of cold and heat in complexity in integrative medicine.
10.19540/j.cnki.cjcmm.20250214.601
- Author:
Ning WANG
1
;
Han-Zhou LI
2
;
Tian-Ze PAN
2
;
Wei-Bo WEN
1
;
Ya-Lin LI
3
;
Qian-Qian WAN
1
;
Yu-Tong JIN
2
;
Yu-Hong BIAN
2
;
Huan-Tian CUI
1
Author Information
1. the First Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650500,China.
2. College of Integrated Traditional Chinese and Western Medicine,Tianjin University of Traditional Chinese Medicine Tianjin 301617,China.
3. Department of Gastroenterology,the First People's Hospital of Yunnan Province Kunming 650500,China.
- Publication Type:English Abstract
- Keywords:
cold and heat in complexity;
colorectal cancer;
inflammation-cancer transformation;
inflammatory bowel disease;
mechanism
- MeSH:
Humans;
Colon/pathology*;
Integrative Medicine;
Animals;
Cold Temperature;
Cell Transformation, Neoplastic/drug effects*;
Medicine, Chinese Traditional;
Hot Temperature;
Inflammation;
Drugs, Chinese Herbal/therapeutic use*;
Colonic Neoplasms/drug therapy*
- From:
China Journal of Chinese Materia Medica
2025;50(10):2605-2618
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC) is one of the most common malignant tumors worldwide, primarily originating from recurrent inflammatory bowel disease(IBD). Therefore, blocking the inflammation-cancer transformation in the colon has become a focus in the early prevention and treatment of CRC. The inflammation-cancer transformation in the colon involves multiple types of cells and complex pathological processes, including inflammatory responses and tumorigenesis. In this complex pathological process, immune cells(including non-specific and specific immune cells) and non-immune cells(such as tumor cells and fibroblasts) interact with each other, collectively promoting the progression of the disease. In traditional Chinese medicine(TCM), inflammation-cancer transformation in the colon belongs to the categories of dysentery and diarrhea, with the main pathogenesis being cold and heat in complexity. This paper first elaborates on the complex molecular mechanisms involved in the inflammation-cancer transformation process in the colon from the perspectives of inflammation, cancer, and their mutual influences. Subsequently, by comparing the pathogenic characteristics and clinical manifestations between inflammation-cancer transformation and the TCM pathogenesis of cold and heat in complexity, this paper explores the intrinsic connections between the two. Furthermore, based on the correlation between inflammation-cancer transformation in the colon and the TCM pathogenesis, this paper delves into the importance of the interaction between inflammation and cancer. Finally, it summarizes and discusses the clinical and basic research progress in the TCM intervention in the inflammation-cancer transformation process, providing a theoretical basis and treatment strategy for the treatment of CRC with integrated traditional Chinese and Western medicine.
