Scientific connotation of "blood stasis toxin" in hypoxic microenvironment: its "soil" function in tumor progression and micro-level treatment approaches.
10.19540/j.cnki.cjcmm.20250310.601
- Author:
Wei FAN
1
;
Yuan-Lin LYU
2
;
Xiao-Chen NI
1
;
Kai-Yuan ZHANG
1
;
Chu-Hang WANG
1
;
Jia-Ning GUO
1
;
Guang-Ji ZHANG
3
;
Jian-Bo HUANG
3
;
Tao JIANG
4
Author Information
1. School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome,Zhejiang Chinese Medical University Hangzhou 310053, China.
2. School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
3. School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome,Zhejiang Chinese Medical University Hangzhou 310053, China Traditional Chinese Medicine "Preventing Disease" Wisdom Health Project Research Center of Zhejiang Hangzhou 310053, China.
4. School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome,Zhejiang Chinese Medical University Hangzhou 310053, China Traditional Chinese Medicine "Preventing Disease" Wisdom Health Project Research Center of Zhejiang Hangzhou 310053, China Zhejiang Culture Research Institute of Chinese Medicine, Zhejiang Chinese Medical University and Key Cultivating Base of Zhejiang Philosophy and Social Sciences Hangzhou 310053, China.
- Publication Type:English Abstract
- Keywords:
angiogenesis;
blood stasis toxin;
hypoxic microenvironment;
micro syndrome differentiation;
tumor
- MeSH:
Humans;
Tumor Microenvironment/drug effects*;
Neoplasms/therapy*;
Animals;
Medicine, Chinese Traditional;
Disease Progression;
Drugs, Chinese Herbal
- From:
China Journal of Chinese Materia Medica
2025;50(12):3483-3488
- CountryChina
- Language:Chinese
-
Abstract:
The tumor microenvironment is a crucial factor in tumor occurrence and progression. The hypoxic microenvironment is widely present in tumor tissue and is a key endogenous factor accelerating tumor deterioration. The "blood stasis toxin" theory, as an emerging perspective in tumor research, is regarded as the unique "soil" in tumor progression from the perspective of traditional Chinese medicine(TCM) due to its dynamic evolution mechanism, which closely resembles the formation of the hypoxic microenvironment. Scientifically integrating TCM theories with the biological characteristics of tumors and exploring precise syndrome differentiation and treatment strategies are key to achieving comprehensive tumor prevention and control. This article focused on the hypoxic microenvironment of the tumor, elucidating its formation mechanisms and evolutionary processes and carefully analyzing the internal relationship between the "blood stasis toxin" theory and the hypoxic microenvironment. Additionally, it explored the interaction among blood stasis, toxic pathogens, and hypoxic environment and proposed micro-level prevention and treatment strategies targeting the hypoxic microenvironment based on the "blood stasis toxin" theory, aiming to provide TCM-based theoretical support and therapeutic approaches for precise regulation of the hypoxic microenvironment.
