Research progress on pentacyclic triterpenoids in medicinal Ilex species and their pharmacological activities.
10.19540/j.cnki.cjcmm.20250210.201
- Author:
Yu-Ling LIU
1
;
Yi-Ran WU
1
;
Bao-Lin WANG
2
;
Xiao-Wei SU
1
;
Qiu-Juan CHEN
1
;
Yi RAO
3
;
Shi-Lin YANG
2
;
Li-Ni HUO
1
;
Hong-Wei GAO
1
Author Information
1. College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China.
2. College of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
3. School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:English Abstract
- Keywords:
Ilex;
anti-inflammatory;
anti-thrombosis;
anti-tumor;
clearing heat and removing toxin;
hypolipidemic;
pentacyclic triterpenoids
- MeSH:
Ilex/chemistry*;
Plants, Medicinal/chemistry*;
Pentacyclic Triterpenes/pharmacology*;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/pharmacology*;
Humans;
Animals
- From:
China Journal of Chinese Materia Medica
2025;50(12):3252-3266
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM) capable of clearing heat and removing toxin is most commonly used in clinical practice and has the effect of removing fire-heat and toxin. Studies have shown that most of the Ilex plants have the effect of clearing heat and removing toxin, among which the varieties of I. cornuta, I. pubescens, I. rotunda, I. latifolia, and I. chinensis are most widely used. These plants generally contain triterpenoids and their glycosides, alkaloids, flavonoids, phenylpropanoids, and other chemical components, especially pentacyclic triterpenoids. According to their skeletons, pentacyclic triterpenoids can be divided into the oleanane type, the ursane type, the lupinane type, etc. Among them, ursane-type components are the most abundant, and 136 species have been found so far. These components have been proved to have pharmacological effects such as anti-inflammatory, anti-tumor, hypolipidemic, anti-thrombosis, cardiomyocyte-protective, antibacterial, and hepatoprotective effects. Therefore, this paper systematically reviews the domestic and foreign literature on Ilex plants with a focus on the research progress on pentacyclic triterpenoids and their pharmacological activities, aiming to provide reference for the development of TCM resources with the effect of clearing heat and removing toxin.
