Research progress on role of competitive endogenous RNA networks in heart failure and intervention by traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20250310.602
- Author:
Pei-Li YANG
1
;
Li-Rong ZHENG
1
;
Ying-Qiang ZHAO
2
Author Information
1. Graduate School, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
2. the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300250, China.
- Publication Type:English Abstract
- Keywords:
circular RNA;
competing endogenous RNA network;
heart failure;
long non-coding RNA;
microRNA;
traditional Chinese medicine
- MeSH:
Humans;
Heart Failure/metabolism*;
Medicine, Chinese Traditional;
Animals;
Drugs, Chinese Herbal/therapeutic use*;
RNA, Circular/genetics*;
RNA, Long Noncoding/metabolism*;
Gene Regulatory Networks/drug effects*;
RNA/metabolism*;
RNA, Competitive Endogenous
- From:
China Journal of Chinese Materia Medica
2025;50(12):3232-3243
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure(HF) is the terminal stage of various cardiovascular diseases, characterized by high morbidity and mortality, and it represents one of the major disease burdens for families and society. In recent years, as research on the molecular mechanisms of HF has deepened, a competing endogenous RNA(ceRNA) network mediated by long non-coding RNAs(lncRNAs) and circular RNAs(circRNAs) has been gradually constructed. Extensive research results have confirmed that the ceRNA network is widely involved in pathological processes such as inflammation, oxidative stress, myocardial hypertrophy, apoptosis, remodeling of extracellular matrix components and structure, and ferroptosis in HF. It reveals the complex pathological mechanisms of HF at the epigenetic level. Traditional Chinese medicine(TCM) plays a unique role in improving symptoms and prognosis of HF and intervenes in the ceRNA network in HF through multi-level and multi-target mechanisms. It improves key pathological processes such as myocardial fibrosis and inflammation, making progress in treating HF at the molecular level. This article summarized recent Chinese and international research on the regulatory mechanisms of ceRNA networks in HF, elaborated on the mechanisms of action of ceRNA networks in different pathological stages of HF, and summarized how effective components and compounds of TCM intervene in the ceRNA network to improve HF, so as to refine the molecular mechanisms of HF and provide directions for more precise molecular targeted therapeutic strategies.
