Network Meta-analysis of efficacy of different Chinese medicine injections in treating transient ischemic attack.
10.19540/j.cnki.cjcmm.20250103.501
- Author:
Jin HAN
1
;
Yong-Kang SUN
2
;
Yue YUAN
3
;
Fang-Biao XU
1
;
Yan-Bo SONG
1
;
Wei-Jie WANG
4
;
Xin-Zhi WANG
5
Author Information
1. Encephalopathy Center,the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450099,China the First Clinical Medical School of Henan University of Chinese Medicine Zhengzhou 450046,China.
2. Encephalopathy Center,the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450099,China Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine Zhengzhou 450046,China.
3. the First Clinical Medical School of Henan University of Chinese Medicine Zhengzhou 450046,China.
4. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450099,China.
5. Encephalopathy Center,the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450099,China Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine Zhengzhou 450046,China Institute of Encephalopathy,Henan Academy of Chinese Medicine Zhengzhou 451163,China.
- Publication Type:Network Meta-Analysis
- Keywords:
Chinese medicine injection;
clinical effect;
network Meta-analysis;
randomized controlled trial;
transient ischemic attack
- MeSH:
Humans;
Drugs, Chinese Herbal/administration & dosage*;
Injections;
Ischemic Attack, Transient/drug therapy*;
Randomized Controlled Trials as Topic;
Treatment Outcome
- From:
China Journal of Chinese Materia Medica
2025;50(8):2282-2297
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to evaluate the efficacy of Chinese medicine injections in treating transient ischemic attack(TIA) based on network Meta-analysis. Randomized controlled trial(RCT) about Chinese medicine injections in treating TIA were retrieved from PubMed, Web of Science, Cochrane Library, EMbase, CNKI, VIP, Wanfang, and SinoMed with the time interval from inception to March 1, 2024. The methodological quality of the included articles was assessed by ROB 2.0, and the GRADE system was employed to evaluate the quality of evidence. The gemtc package of R 4.1.2 was used to perform the network Meta-analysis. Finally, 63 RCTs with a total sample size of 5 750 cases were included, involving 11 Chinese medicine injections(Shuxuetong Injection, Danhong Injection, Shuxuening Injection, Ginkgo Damo Injection, Shenxiong Glucose Injection, Ligustrazine Injection, Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection, Salvianolic Acids for Injection, Dengzhan Xixin Injection, Guhong Injection, and Xueshuantong Injection). All patients received conventional western medicine treatment, and the experimental group was additionally treated with Chinese medicine injection. Network Meta-analysis yielded the following results.(1) In terms of improving the clinical total response rate, 11 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Dengzhan Xixin Injection + conventional western medicine had the best effect.(2) In terms of reducing plasma viscosity, 7 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Shenxiong Glucose Injection + conventional western medicine had the best effect.(3) In terms of reducing whole blood high shear viscosity, 6 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Guhong Injection + conventional western medicine had the best effect.(4) In terms of reducing whole blood low shear viscosity, 6 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Shuxuening Injection + conventional western medicine had the best effect.(5) In terms of reducing fibrinogen, 9 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Ginkgo Damo Injection + conventional western medicine had the best effect.(6) In terms of increasing the average blood flow velocity, 3 Chinese medicine injections combined with conventional western medicine outperformed conventional western medicine alone, and Shuxuening Injection + conventional western medicine had the best effect. In summary, compared with conventional western medicine alone, Chinese medicine injections combined with conventional western medicine were effective in improving the clinical total response rate and the average blood flow velocity, as well as reducing plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and fibrinogen. However, due to the limited quality and quantity of the included articles, the above conclusions need to be verified by more high-quality, multi-center, and large-sample RCT.
