One new sesquiterpene from Aquilariae Lignum Resinatum.
10.19540/j.cnki.cjcmm.20250204.201
- Author:
Jia-Min CAO
1
;
Bin HU
1
;
De-Shang MAI
1
;
Cai-Xin CHEN
1
;
Zhong-Xiang ZHAO
2
;
Wei-Qun YANG
1
Author Information
1. State Key Laboratory of Traditional Chinese Medicine Syndrome, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine Guangzhou 510006, China.
2. State Key Laboratory of Traditional Chinese Medicine Syndrome, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine Guangzhou 510006, China Chinese Medicine Guangdong Laboratory Hengqin 519000, China.
- Publication Type:Journal Article
- Keywords:
(+)-(7R,10R)-selina-4,11-dien-12-dimethoxy-15-al;
Aquilariae Lignum Resinatum;
eudesmane-type sesquiterpene;
sesquiterpene
- MeSH:
Sesquiterpenes/isolation & purification*;
Thymelaeaceae/chemistry*;
Molecular Structure;
Drugs, Chinese Herbal/isolation & purification*;
Magnetic Resonance Spectroscopy
- From:
China Journal of Chinese Materia Medica
2025;50(8):2167-2172
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of sesquiterpenes from 95% ethanol extract of Aquilariae Lignum Resinatum were isolated and purified by various column chromatography techniques, including silica gel, Sephadex LH-20, octadecylsilyl(ODS), and semi-preparative high performance liquid chromatography(HPLC). Their planar structures and absolute configurations were elucidated by ultraviolet(UV) spectrometry, infrared(IR) spectroscopy, mass spectrometry(MS), nuclear magnetic resonance(NMR), electronic circular dichroism(ECD), and other techniques. Eight sesquiterpenoids were isolated and identified as(+)-(7R,10R)-selina-4,11-dien-12-dimethoxy-15-al(1),(+)-(7R,10R)-selina-4,11-diene-12,15-dial(2), agalleudesmanol B(3), aquisinenoid C(4), 12,15-dioxo-α-selinen(5), agarospiranic aldehyde B(6), neopetasane(7), and eremophila-7(11),9-dien-8-one(8). Compound 1 was a new compound, and it was the first time to find a dimethoxy substitution on the side chain of eudesmane-type sesquiterpene skeleton.
