Advances in pathogenesis of asthma airway remodeling and intervention mechanism of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20241212.705
- Author:
Ya-Sheng DENG
1
;
Jiang LIN
1
;
Yu-Jiang XI
2
;
Yan-Ping FAN
1
;
Wen-Yue LI
1
;
Yong-Hui LIU
1
;
Zhao-Bing NI
1
;
Xi MING
2
Author Information
1. Guangxi University of Chinese Medicine Nanning 530200, China.
2. the First Clinical Medical College, Yunnan University of Chinese Medicine Kunming 650051, China.
- Publication Type:English Abstract
- Keywords:
airway remodeling;
asthma;
pathogenesis;
research progress;
traditional Chinese medicine active ingredients;
traditional Chinese medicine complexes;
traditional Chinese medicine extracts
- MeSH:
Asthma/pathology*;
Humans;
Airway Remodeling/drug effects*;
Drugs, Chinese Herbal/therapeutic use*;
Animals;
Signal Transduction/drug effects*;
Medicine, Chinese Traditional;
Transforming Growth Factor beta1/metabolism*
- From:
China Journal of Chinese Materia Medica
2025;50(8):2050-2070
- CountryChina
- Language:Chinese
-
Abstract:
Asthma, a chronic inflammatory airway disease with a high global prevalence, has a complex pathogenesis, in which airway remodeling plays a key role in the chronicity of the disease. Airway remodeling involves a series of pathophysiological changes, including airway epithelial damage, proliferation of mucous glands and goblet cells, subepithelial fibrosis, proliferation and migration of airway smooth muscle cells, and epithelial-mesenchymal transition. These complex pathological changes significantly increase airway resistance and responsiveness, forming an important pathological basis for refractory asthma. Currently, the regulatory mechanisms of airway remodeling focus on signaling pathways and regulatory targets. The signaling pathways include phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt), nuclear factor-κB(NF-κB), transforming growth factor-β1(TGF-β1)/Smads, and mitogen-activated protein kinase(MAPK). The regulatory targets include microRNAs(miRNAs), competing endogenous RNAs(ceRNAs), long non-coding RNAs(lncRNAs), and circular RNAs(circRNAs). Key proteins involved in these processes include TGF-β1, silencing information regulator 2-related enzyme 1(SIRT1), chitinase 3-like protein 1(YKL-40), and adenosine deaminase-metalloproteinase 33(ADAM33). In recent years, the potential of traditional Chinese medicine in the treatment of asthma has become increasingly evident. Its active ingredients, extracts, and complexes can inhibit airway remodeling in asthma through multiple pathways, demonstrating a variety of effects, including anti-inflammatory actions, inhibition of smooth muscle cell proliferation and migration, regulation of epithelial-mesenchymal transition, attenuation of fibrosis and basement membrane thickening, reduction of mucus secretion, inhibition of vascular remodeling, modulation of immune imbalance, and antioxidative stress. This paper aims to provide an in-depth analysis of the pathogenesis and therapeutic targets of asthma, offering theoretical support and innovative strategies for clinical research and drug development in the treatment of asthma.
