Research progress in mechanisms of herb pairs in treating ischemic stroke.
10.19540/j.cnki.cjcmm.20250106.601
- Author:
Shu ZHANG
1
;
Chun-Long RAN
2
;
Chi-Yuan MA
2
;
Xiang-Zhe LIU
2
Author Information
1. Encephalopathy Center, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450046, China the First Clinical Medical School, Henan University of Chinese Medicine Zhengzhou 450000, China.
2. Encephalopathy Center, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450046, China.
- Publication Type:English Abstract
- Keywords:
herb pair;
ischemic stroke;
pharmacological mechanism;
review
- MeSH:
Humans;
Drugs, Chinese Herbal/chemistry*;
Animals;
Ischemic Stroke/metabolism*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2025;50(8):2041-2049
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke(IS) is a complex pathological process involving multiple cellular and molecular mechanisms and it is characterized by high mortality, high disability, and high recurrence. In recent years, the incidence of IS in China has been increasing year by year, and it has a trend of occurring in increasingly young individuals. Herb pairs are the smallest unit of traditional Chinese medicine(TCM) compatibility and an important part of TCM compounding, and the research on them is of great significance in guiding the clinical medication. Pharmacological studies have confirmed that certain herb pairs can exert anti-ischemic effects through various pathways such as reducing inflammation, alleviating oxidative stress, protecting the nervous system, and promoting neovascularization. By reviewing the relevant articles in the past decade, this paper probes into the combination rules, modern experimental studies, and combination ratios of the commonly used herb pairs from the etiology and pathogenesis of IS and summarizes 18 commonly used and deeply studied herb pairs, with a view to providing reference for the application, research, and development of clinical medicines.
