Research on software development and smart manufacturing platform incorporating near-infrared spectroscopy for measuring traditional Chinese medicine manufacturing process.
10.19540/j.cnki.cjcmm.20250226.301
- Author:
Yan-Fei WU
1
;
Hui XU
1
;
Kai-Yi WANG
2
;
Hui-Min FENG
2
;
Xiao-Yi LIU
2
;
Nan LI
3
;
Zhi-Jian ZHONG
4
;
Ze-Xiu ZHANG
5
;
Zhi-Sheng WU
6
Author Information
1. College of Pharmacy,Gansu University of Chinese Medicine Lanzhou 730000,China.
2. School of Chinese Materia Medica,Beijing Univesity of Chinese Medicine Beijing 102488,China.
3. School of Chinese Materia Medica,Beijing Univesity of Chinese Medicine Beijing 102488,China Engineering Research Center of Chinese Medicine Production and New Drug Development Beijing 102488,China.
4. China Resources Pharmaceutical Group Limited Nanchang 330096,China.
5. Zhangzhou Pien Tze Huang Pharmaceutical Co.,Ltd. Zhangzhou 363000,China Fujian Provincial Key Laboratory of Pien Tze Huang Natural Medicine Research and Development Zhangzhou 363000,China.
6. College of Pharmacy,Gansu University of Chinese Medicine Lanzhou 730000,China School of Chinese Materia Medica,Beijing Univesity of Chinese Medicine Beijing 102488,China Engineering Research Center of Chinese Medicine Production and New Drug Development Beijing 102488,China.
- Publication Type:English Abstract
- Keywords:
measurement of traditional Chinese medicine(TCM) manufacturing process;
methodological validation;
near-infrared spectroscopy;
smart factory;
software development
- MeSH:
Spectroscopy, Near-Infrared/methods*;
Drugs, Chinese Herbal/analysis*;
Software;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2025;50(9):2324-2333
- CountryChina
- Language:Chinese
-
Abstract:
Process analytical technology(PAT) is a key means for digital transformation and upgrading of the traditional Chinese medicine(TCM) manufacturing process, serving as an important guarantee for consistent and controllable TCM product quality. Near-infrared(NIR) spectroscopy has become the core technology for measuring the TCM manufacturing process. By incorporating NIR spectroscopy into PAT and starting from the construction of a smart platform for the TCM manufacturing process, this paper systematically described the development history and innovative application of the combination of NIR spectroscopy with chemometrics in measuring the TCM manufacturing process by the research team over the past two decades. Additionally, it explored the application of a validation method based on accuracy profile(AP) in the practice of NIR spectroscopy. Furthermore, the software development progress driven by NIR spectroscopy supported by modeling technology was analyzed, and the prospect of integrating NIR spectroscopy in smart factory control platforms was exemplified with the construction practices of related platforms. By integrating with the smart platform, NIR spectroscopy could improve production efficiency and guarantee product quality. Finally, the prospect of the smart platform application in measuring the TCM manufacturing process was projected. It is believed that the software development for NIR spectroscopy and the smart manufacturing platform will provide strong technical support for TCM digitalization and industrialization.
