Four new diglycosides from Momordicae Semen.
10.19540/j.cnki.cjcmm.20241213.202
- Author:
Cheng-Lin ZHOU
1
;
Xiao-Bo LI
1
;
Pei-Jun JU
2
;
Ru DING
1
;
Meng-Yue WANG
1
Author Information
1. School of Pharmaceutical Science, Shanghai Jiao Tong University Shanghai 200240, China.
2. Shanghai Institute of Traditional Chinese Medicine for Mental Health Shanghai 200030, China.
- Publication Type:Journal Article
- Keywords:
Momordicae Semen;
chemical constituents;
diglycoside;
mubeside;
seed kernel
- MeSH:
Glycosides/isolation & purification*;
Drugs, Chinese Herbal/isolation & purification*;
Molecular Structure;
Magnetic Resonance Spectroscopy;
Chromatography, High Pressure Liquid
- From:
China Journal of Chinese Materia Medica
2025;50(6):1558-1563
- CountryChina
- Language:Chinese
-
Abstract:
The seed kernel of Momordica cochinchinensis, i.e., Momordicae Semen, is used for medicinal purposes, but to date, no research has been reported on its chemical constituents. In this study, the chemical constituents of Momordicae Semen were investigated for the first time using silica gel column chromatography, semi-preparative HPLC, HR-MS, and NMR. As a result, eight compounds were isolated and identified as: p-hydroxybenzoic acid-7-O-trehaloside(mubeside A, 1), 2,6-dimethoxyphenol-O-β-D-apiosyl-(1→2)-β-D-glucoside(mubeside B, 2), 1-O-p-methoxybenzoyl-1,4-benzenediol-4-O-β-D-apiosyl-(1→2)-β-D-glucoside(mubeside C, 3), 1-O-p-hydroxybenzoyl-1,4-benzenediol-4-O-β-D-apiosyl-(1→2)-β-D-glucoside(mubeside D, 4), gypsogenin-3-O-β-D-galactosyl-(1→2)-β-D-glucuronoside(5), quillaic acid-3-O-β-D-galactosyl-(1→2)-β-D-glucuronoside(6), violanthin(7), and kaempferitrin(8). Compounds 1-4 are new compounds, while compounds 5-8 were isolated from Momordicae Semen for the first time.
