Research progress in effect of traditional Chinese medicine on aerobic glycolysis in colorectal cancer.
10.19540/j.cnki.cjcmm.20241224.501
- Author:
Xu MA
1
;
Sheng-Long LI
1
;
Guang-Rong ZHENG
1
;
Da-Cheng TIAN
1
;
Gang-Gang LU
1
;
Jie GAO
1
;
Yu-Qi AN
1
;
Li-Yuan CAO
1
;
Liang LI
2
;
Xiao-Yong TANG
2
Author Information
1. School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China.
2. Department of General Surgery, Gansu Provincial Hospital of Traditional Chinese Medicine Lanzhou 730050, China.
- Publication Type:English Abstract
- Keywords:
aerobic glycolysis;
colorectal cancer;
review;
traditional Chinese medicine
- MeSH:
Humans;
Colorectal Neoplasms/genetics*;
Drugs, Chinese Herbal/therapeutic use*;
Glycolysis/drug effects*;
Animals;
Medicine, Chinese Traditional;
Signal Transduction/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(6):1496-1506
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer(CRC) is a common malignant tumor worldwide. Due to the treatment intolerance and side effects, CRC rank the top among various cancers regarding the incidence and mortality rates. Therefore, exploring new therapies is of great significance for the treatment of CRC. Aerobic glycolysis(AEG) plays an important role in the microenvironment formation, proliferation, metastasis, and recurrence of CRC and other tumor cells. It has been confirmed that intervening in the AEG pathway can effectively curb CRC. The active ingredients and compound prescriptions of traditional Chinese medicine(TCM) can effectively inhibit the proliferation, metastasis, and drug resistance and regulate the apoptosis of tumor cells by modulating AEG-associated transport proteins [eg, glucose transporters(GLUT)], key enzymes [hexokinase(HK) and phosphofructokinase(PFK)], key genes [hypoxia-inducible factor 1(HIF-1) and oncogene(c-Myc)], and signaling pathways(MET/PI3K/Akt/mTOR). Accordingly, they can treat CRC, reduce the recurrence, and improve the prognosis of CRC. Although AEG plays a key role in the development and progression of CRC, the specific mechanisms are not yet fully understood. Therefore, this article delves into the intrinsic connection of the targets and mechanisms of the AEG pathway with CRC from the perspective of tumor cell glycolysis and explores how active ingredients(oxymatrine, kaempferol, and dioscin) and compound prescriptions(Quxie Capsules, Jiedu Sangen Decoction, and Xianlian Jiedu Prescription) of TCM treat CRC by intervening in the AEG pathway. Additionally, this article explores the shortcomings in the current research, aiming to provide reliable targets and a theoretical basis for treating CRC with TCM.
