Pharmacological effect and mechanism of tannic acids in Paeoniae Radix Alba.
10.19540/j.cnki.cjcmm.20241219.301
- Author:
Jia-Xin DIAO
1
;
Qi-Tong ZHENG
1
;
Meng-Yao CHEN
1
;
Jiang-Chuan HONG
1
;
Min HAO
1
;
Qing-Mei FENG
2
;
Jun-Qi HU
3
;
Xia-Nan SANG
1
;
Gang CAO
1
Author Information
1. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 311402, China.
2. College of Chemical and Biological Engineering, Xingtai University Xingtai 054000, China.
3. Department of Respiratory and Critical Care Medicine, Zhejiang Provincial Hospital of Chinese Medicine Hangzhou 311402, China.
- Publication Type:English Abstract
- Keywords:
Paeoniae Radix Alba;
mechanism;
pharmacological activity;
structure and property;
tannic acid
- MeSH:
Paeonia/chemistry*;
Tannins/chemistry*;
Humans;
Drugs, Chinese Herbal/chemistry*;
Animals;
Plant Extracts
- From:
China Journal of Chinese Materia Medica
2025;50(6):1471-1483
- CountryChina
- Language:Chinese
-
Abstract:
The chemical composition of Paeoniae Radix Alba(PRA) is complex, with primary secondary metabolites including monoterpenoids, tannins, triterpenoids, and flavonoids. In previous studies on the material basis of PRA, it was found that, in addition to the widely studied characteristic monoterpene glycosides, tannic acid components also play an important role in the efficacy of PRA. However, their pharmacological effects have not been thoroughly investigated. This paper reviews the tannic acid components in PRA, including pentagaloyl glucose(PGG), tetragaloyl glucose(TGG), trigaloyl glucose(TriGG), and gallic acid, along with their structures, properties, and characteristics to provide a detailed discussion of their pharmacological activities and related mechanisms, aiming to offer a theoretical basis for the material basis research and clinical application of PRA.
