Research advances in mechanism of salvianolic acid B in treating coronary heart disease.
10.19540/j.cnki.cjcmm.20241213.601
- Author:
Hong-Ming CAO
1
;
Hui SUN
1
;
Chang LIU
1
;
Guang-Li YAN
1
;
Ling KONG
1
;
Ying HAN
1
;
Xi-Jun WANG
1
Author Information
1. Chinmedomics Research Center of National Administration of Traditional Chinese Medicine,State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Heilongjiang University of Chinese Medicine Harbin 150040, China.
- Publication Type:English Abstract
- Keywords:
Salviae Miltiorrhizae Radix et Rhizoma;
coronary heart disease;
myocardial damage;
salvianolic acid B;
thrombus
- MeSH:
Humans;
Benzofurans/administration & dosage*;
Coronary Disease/genetics*;
Drugs, Chinese Herbal/administration & dosage*;
Salvia miltiorrhiza/chemistry*;
Animals;
Depsides
- From:
China Journal of Chinese Materia Medica
2025;50(6):1449-1457
- CountryChina
- Language:Chinese
-
Abstract:
Coronary heart disease is a cardiovascular disease that affects coronary arteries. It presents high incidence and high mortality worldwide, bringing a serious threat to human health and quality of life. Salviae Miltiorrhizae Radix et Rhizoma derived from Salvia miltiorrhiza is widely used in the treatment of cardiovascular diseases, such as coronary heart disease. Salvianolic acid B is an active component in Salviae Miltiorrhizae Radix et Rhizoma extracts, and studies have shown that it has anti-inflammatory, antioxidant, apoptosis-and autophagy-regulating, anti-fibrosis, and metabolism-modulating effects. This article reviews the research progress regarding the therapeutic effect of salvianolic acid B on coronary heart disease in the recent decade. It elaborates on the role and mechanism of salvianolic acid B in treating coronary heart disease from multiple perspectives, such as the inhibition of thrombosis, improvement of blood circulation, reduction of myocardial cell injury, and inhibition of cardiac remodeling. This article provides a theoretical basis for the application of Chinese medicinal materials and TCM prescriptions containing salvianolic acid B in the treatment of coronary heart disease.
