Treatment of allergic rhinitis in children by attenuating oxidative stress from sweat pore-Qi-triple energizer system.
10.19540/j.cnki.cjcmm.20241115.501
- Author:
Yu-Zhu DOU
1
;
Qi-Gang DAI
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.
- Publication Type:English Abstract
- Keywords:
allergic rhinitis;
oxidative stress;
sweat pore-Qi-triple energizer system
- MeSH:
Humans;
Oxidative Stress/drug effects*;
Rhinitis, Allergic/metabolism*;
Child;
Qi;
Sweat/metabolism*;
Drugs, Chinese Herbal/administration & dosage*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2025;50(5):1419-1426
- CountryChina
- Language:Chinese
-
Abstract:
Sweat pores function is the ascending and descending of Qi. The human body maintains a continuous, holistic, and dynamic balance through the functioning of sweat pores as well as the Qi movement and transformation in the spleen, stomach, and triple energizer. Sweat pores play a crucial role in the generation and development of Zang-fu organs, essence and spirit, and body and orifices, as well as in the onset and progression of diseases. Oxidative stress significantly affects the regulation of inflammation in allergic rhinitis(AR), induces the pathological damage to nasal epithelial cells, and alters immune activity, serving as a key mechanism exacerbating AR symptoms. This mechanism closely aligns with the pathogenesis associated with dysfunction in the sweat pore-Qi-triple energizer system. In recent years, oxidative stress and antioxidants in AR have received increasing attention. Elevated levels of reactive oxygen species, fractional exhaled nitric oxide, and malondialdehyde have become key indicators for the early diagnosis of AR. Classical prescriptions, empirical prescriptions, and newly developed preparations of traditional Chinese medicine(TCM) for external use with anti-inflammatory, anti-allergic, and immune-regulatory effects via antioxidant pathways have demonstrated definite efficacy in treating AR. This provides a basis for understanding the pathogenesis of AR in TCM from a modern medical perspective. Therefore, this paper systematically examines the relationship between the sweat pore-Qi-triple energizer system and AR, incorporating the oxidative stress mechanism into the research on pathogenesis of the disorders. Furthermore, methods for treating AR in children are proposed with TCM preparations for external use which aimed at opening nasal sweat pores, dispersing, searching, channeling with aroma, warming, and dredging, regulating Qi movement in spleen, warming Yang Qi to promote urination, and clearing latent wind to inhibit liver depression.
