A new triterpenoid from Elephantopus scaber.
10.19540/j.cnki.cjcmm.20241216.201
- Author:
Zu-Xiao DING
1
;
Hong-Xi XIE
2
;
Lin CHEN
2
;
Jun-Jie HAO
3
;
Yan-Qiu LUO
2
;
Zhi-Yong JIANG
2
;
Shi-Kui XU
4
Author Information
1. Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmacy, Kunming Medical University Kunming 650500, China.
2. Key Laboratory of Dai and Yi Medicine in Yunnan Province, Key Laboratory of Modern Research on Ethnic Medicine in Yunnan Provincial Universities, School of Ethnomedicine, Yunnan University of Chinese Medicine Kunming 650500, China.
3. College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine Kunming 650500, China.
4. Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmacy, Kunming Medical University Kunming 650500, China MIIT Public Service Platform for Industrial Technology Foundation, Yunnan Institute for Food and Drug Control Kunming 650106, China.
- Publication Type:Journal Article
- Keywords:
3β-hydroxy-6β,7β-epoxytaraxeran-14-ene;
Elephantopus scaber;
triterpenoid
- MeSH:
Triterpenes/isolation & purification*;
Drugs, Chinese Herbal/isolation & purification*;
Molecular Structure;
Asteraceae/chemistry*;
Chromatography, High Pressure Liquid;
Magnetic Resonance Spectroscopy
- From:
China Journal of Chinese Materia Medica
2025;50(5):1224-1230
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of the petroleum ether extract derived from the 90% ethanol extract of Elephantopus scaber were investigated. By silica gel column chromatography, C_(18), MCI column chromatography and semi-preparative high performance liquid chromatography, ten compounds were isolated. Their structures were identified as 3β-hydroxy-6β,7β-epoxytaraxeran-14-ene(1), 3β-hydroxyolean-12-en-28-oic acid(2), D-friedoolean-14-ene-3β,7α-diol(3), 3β-hydroxy-11α-methoxyolean-12-ene(4), 3β-hydroxyolean-11,13(18)-diene(5), 11α-hydroxy-β-amyrin(6), betulinic acid(7), 3β-hydroxy-30-norlupan-20-one(8), 6-acetonylchelerythrine(9), and 4',5'-dehydrodiodictyonema A(10) by analysis of the 1D NMR, 2D NMR, MS, and IR spectral data. Among them, compound 1 was a new triterpene and other compounds except compounds 2 and 7 were isolated from this plant for the first time.
