Biosynthesis of ganoderic acid and its derivatives.
10.19540/j.cnki.cjcmm.20241215.105
- Author:
Hong-Yan SONG
1
;
Wan YANG
1
;
Li-Wei LIU
1
;
Xia-Ying CHENG
1
;
Dong-Feng YANG
2
;
Zong-Qi YANG
1
Author Information
1. Zhejiang Key Laboratory of Plant Secondary Metabolism and Regulation, College of Life Science and Medicine, Zhejiang Sci-Tech University Hangzhou 310018, China.
2. Zhejiang Key Laboratory of Plant Secondary Metabolism and Regulation, College of Life Science and Medicine, Zhejiang Sci-Tech University Hangzhou 310018, China Zhejiang Engineering Research Center for the Development Technology of Medicinal and Edible Health Food, Shaoxing Academy of Biomedicne Co., Ltd., Zhejiang Sci-Tech University Shaoxing 312366, China.
- Publication Type:English Abstract
- Keywords:
Ganoderma lucidum;
biosynthesis;
ganoderic acid;
metabolic regulation
- MeSH:
Triterpenes/chemistry*;
Reishi/chemistry*;
Biosynthetic Pathways;
Lanosterol
- From:
China Journal of Chinese Materia Medica
2025;50(5):1155-1163
- CountryChina
- Language:Chinese
-
Abstract:
Ganoderic acid is a class of lanostane-type triterpenoids found in Ganoderma species, and is one of the most important pharmacologically active components in G. lucidum, exhibiting antioxidant, anti-neuropsychiatric, anti-tumor, and immune-enhancing properties. The content of ganoderic acid in G. lucidum is very low, and the traditional extraction process is complex, yielding minimal amounts at high cost. The biosynthetic pathway of G. lucidum triterpenoids(GLTs), including the synthesis of different structural forms of ganoderic acid from lanosterol, as well as the molecular regulatory mechanisms involving key regulatory enzyme genes and their functions, are not yet fully understood. With the continuous development of synthetic biology technologies, there has been a deeper understanding of the biosynthesis and metabolic regulation pathways of ganoderic acid and its derivatives at the molecular level. Research has explored the key regulatory enzyme genes related to ganoderic acid biosynthesis and their functions. Moreover, through the optimization of synthetic biology and culture conditions, large-scale production and preparation of GLTs at the cellular level have been achieved. This paper reviews and analyzes the latest research progress on the biosynthesis pathways and metabolic regulation of GLTs, focusing on the configuration of ganoderic acid and its derivatives, the biosynthetic pathways, key enzyme genes, transcription factors related to ganoderic acid biosynthesis, signal transduction mechanisms, and factors affecting triterpenoid biotransformation. This review is expected to provide a theoretical basis and technical reference for improving the efficient production of triterpenoid pharmacological components and the exploitation and utilization of G. lucidum resources.
