"Component-effect" correlations in traditional Chinese medicine from holistic view: taking discovery of gintonin from ginseng as an example.
10.19540/j.cnki.cjcmm.20250201.202
- Author:
Xin-Ming YU
1
;
Chen-Yu YU
1
;
Hua-Ying WANG
1
;
Wei-Sheng YUE
1
;
Zhu-Bin ZHANG
1
;
Wei WU
2
;
Xiao-Bin JIA
1
;
Bing YANG
1
;
Liang FENG
2
Author Information
1. Affiliated Jiangning Traditional Chinese Medicine Hospital, School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
2. Affiliated Jiangning Traditional Chinese Medicine Hospital, School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China Nanjing Jiangning Hospital of Traditional Chinese Medicine Nanjing 211198, China.
- Publication Type:Journal Article
- Keywords:
component structure;
ginsenosides;
gintonin;
holistic view;
pharmacological action
- MeSH:
Panax/chemistry*;
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Humans;
Ginsenosides/pharmacology*;
Animals
- From:
China Journal of Chinese Materia Medica
2025;50(7):2001-2012
- CountryChina
- Language:Chinese
-
Abstract:
The holistic view is the key in the study of traditional Chinese medicine(TCM). The component structure theory is based on the holistic view to investigate the correlation between material basis and efficiency, which enriches the holistic "component-effect" research of TCM. Gintonin is a newly isolated non-saponin component of ginseng. Compared to ginsenosides, gintonin has many different pharmacological activities, and it provides new knowledge for the holistic research of ginseng. Thus, taking the discovery of gintonin from ginseng as an example, this paper explored the linkage between ginsenosides and gintonin from the perspective of "component-effect" correlations and systematically sorted out the similarities and differences between them in terms of structural characteristics, modes of action, and pharmacological activities. Starting from the collaborative interaction of TCM compounds, the study discussed the application and value of the holistic view in TCM "component-effect" research in the light of the component structure theory to provide new thoughts for the development of modern TCM research.
