Heart Yin deficiency and cardiac fibrosis: from pathological mechanisms to therapeutic strategies.
10.19540/j.cnki.cjcmm.20250124.601
- Author:
Jia-Hui CHEN
1
;
Si-Jing LI
2
;
Xiao-Jiao ZHANG
2
;
Zi-Ru LI
2
;
Xing-Ling HE
2
;
Xing-Ling CHEN
3
;
Tao-Chun YE
4
;
Zhi-Ying LIU
5
;
Hui-Li LIAO
5
;
Lu LU
3
;
Zhong-Qi YANG
1
;
Shi-Hao NI
6
Author Information
1. State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China Department of Geriatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China.
2. State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Guangzhou 510407, China.
3. Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Guangzhou 510407, China.
4. Department of Cardiopulmonary Rehabilitation, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China.
5. Department of Geriatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China.
6. State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China Department of Geriatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407, China Guangdong Clinical Research Institute of Chinese Medicine Guangzhou 510407, China Lingnan Medical Research Center, Guangzhou University of Chinese Medicine Guangzhou 510407, China.
- Publication Type:English Abstract
- Keywords:
blood stasis and water retention;
cardiac fibrosis;
heart Yin deficiency;
nourishing Yin,activating blood,and promoting urination
- MeSH:
Humans;
Fibrosis/drug therapy*;
Animals;
Yin Deficiency/metabolism*;
Myocardium/metabolism*;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2025;50(7):1987-1993
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac fibrosis(CF) is a cardiac pathological process characterized by excessive deposition of extracellular matrix(ECM). When the heart is damaged by adverse stimuli, cardiac fibroblasts are activated and secrete a large amount of ECM, leading to changes in cardiac fibrosis, myocardial stiffness, and cardiac function declines and accelerating the development of heart failure. There is a close relationship between heart yin deficiency and cardiac fibrosis, which have similar pathogenic mechanisms. Heart Yin deficiency, characterized by insufficient Yin fluids, causes the heart to lose its nourishing function, which acts as the initiating factor for myocardial dystrophy. The deficiency of body fluids leads to stagnation of blood flow, resulting in blood stasis and water retention. Blood stasis and water retention accumulate in the heart, which aligns with the pathological manifestation of excessive deposition of ECM, as a tangible pathogenic factor. This is an inevitable stage of the disease process. The lingering of blood stasis combined with water retention eventually leads to the generation of heat and toxins, triggering inflammatory responses similar to heat toxins, which continuously stimulate the heart and cause the ultimate outcome of CF. Considering the syndrome of heart Yin deficiency, traditional Chinese medicine capable of nourishing Yin, activating blood, and promoting urination can reduce myocardial cell apoptosis, inhibit fibroblast activation, and lower the inflammation level, showing significant advantages in combating CF.
