Two new sesquiterpenoids from Aucklandiae Radix and their farnesoid X receptor agonist activity.
10.19540/j.cnki.cjcmm.20250107.201
- Author:
Qian-Yu CHEN
1
;
Dan HUANG
1
;
Hong-Hong ZHAN
1
;
Fan-Cheng MENG
1
;
Guo-Wei WANG
1
;
Min CHEN
2
Author Information
1. Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University,College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China.
2. Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University,College of Pharmaceutical Sciences, Southwest University Chongqing 400715, China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu 611137, China.
- Publication Type:Journal Article
- Keywords:
Aucklandiae Radix;
farnesoid X receptor;
high content screening;
sesquiterpenoids
- MeSH:
Receptors, Cytoplasmic and Nuclear/genetics*;
Humans;
Sesquiterpenes/isolation & purification*;
Drugs, Chinese Herbal/isolation & purification*;
Cell Line;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2025;50(7):1810-1816
- CountryChina
- Language:Chinese
-
Abstract:
Various chromatographic methods were comprehensively applied to study the chemical composition of the ethyl acetate extract from Aucklandiae Radix. The structures of all compounds were identified by analyzing their physicochemical properties and using spectroscopic methods. Two new sesquiterpenoids, named auclappsines A and B(1 and 2) were isolated and identified. Through in vitro high content screening and with the use of a guggulsterone-induced L02 cells, the effects of 1 and 2 on farnesoid X receptor(FXR) protein expression were investigated. The results showed that 1 had a significant FXR activation effect, providing a scientific basis for the development of drugs for the treatment of liver and gallbladder diseases.
