A new sesquiterpenoid from fresh herb of Centipeda minima.
10.19540/j.cnki.cjcmm.20250205.201
- Author:
Qi-Ji LI
1
;
Liu YANG
2
;
Li WANG
2
;
Lang ZHOU
2
;
Yan YANG
2
;
Juan YANG
1
Author Information
1. State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine,Guizhou Medical University Guiyang 550014, China Institute for Development of Functional Natural Products,Natural Products Research Center of Guizhou Province Guiyang 550014, China.
2. Institute for Development of Functional Natural Products,Natural Products Research Center of Guizhou Province Guiyang 550014, China.
- Publication Type:Journal Article
- Keywords:
Centipeda minima;
anti-inflammatory activity;
chemical constituents;
minimin A;
sesquiterpenoids
- MeSH:
Sesquiterpenes/pharmacology*;
Animals;
Asteraceae/chemistry*;
Mice;
Drugs, Chinese Herbal/pharmacology*;
Molecular Structure;
Magnetic Resonance Spectroscopy;
Macrophages/immunology*
- From:
China Journal of Chinese Materia Medica
2025;50(7):1803-1809
- CountryChina
- Language:Chinese
-
Abstract:
Eleven sesquiterpenoids were isolated from the petroleum ether and ethyl acetate extracted fraction of 95% ethanol extract of fresh Centipeda minima by using modern chromatographic separation techniques such as silica gel, MCI, gel, and semi-preparative liquid chromatography. Their structures were identified using spectroscopy and nuclear magnetic resonance(NMR) calculation as minimin A(1), brevilin A(2), minimolide L(3), minimolide A(4), minimolide B(5), arnicolide D(6), microhelenin C(7), 2β-hydroxyl-2,3-dihydrogen-6-O-angeloylplenolin(8), 11α,13-dihydroarnifolin(9),(1S,2R,5R,6S,7S,8S,10R)-6-hydroxy-2-ethoxy-4-oxopseudoguai-11(13)-en-12,8-olide(10), and pulchellin-2-O-isovalerate(11), among which compound 1 was a new compound, and compounds 9-11 were isolated from Centipeda for the first time. The evaluation results of in vitro anti-inflammatory activity showed that compounds 1-11 possessed significant anti-inflammatory activity, with IC_(50) values ranging from(0.13±0.03) to(13.11±0.17) μmol·L~(-1).
