Anti-tumor effect of metal ion-mediated natural small molecules carrier-free hydrogel combined with CDT/PDT.
10.19540/j.cnki.cjcmm.20240206.302
- Author:
Wen-Min PI
1
;
Gen LI
1
;
Xin-Ru TAN
1
;
Zhi-Xia WANG
1
;
Xiao-Yu LIN
1
;
Hai-Ling QIU
1
;
Fu-Hao CHU
1
;
Bo WANG
2
;
Peng-Long WANG
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University Beijing 100070, China.
- Publication Type:Journal Article
- Keywords:
anti-tumor;
chemodynamic therapy(CDT);
natural small molecules carrier-free hydrogel;
photodynamic therapy(PDT);
synergistic therapy
- MeSH:
Hydrogels/chemistry*;
Animals;
Photochemotherapy;
Humans;
Mice;
Antineoplastic Agents/administration & dosage*;
Photosensitizing Agents/chemistry*;
Neoplasms/metabolism*;
Female;
Copper/chemistry*;
Reactive Oxygen Species/metabolism*;
Tumor Microenvironment/drug effects*;
Cell Line, Tumor;
Male
- From:
China Journal of Chinese Materia Medica
2025;50(7):1770-1780
- CountryChina
- Language:Chinese
-
Abstract:
Metal ion-promoted chemodynamic therapy(CDT) combined with photodynamic therapy(PDT) offers broad application prospects for enhancing anti-tumor effects. In this study, glycyrrhizic acid(GA), copper ions(Cu~(2+)), and norcantharidin(NCTD) were co-assembled to successfully prepare a natural small-molecule, carrier-free hydrogel(NCTD Gel) with excellent material properties. Under 808 nm laser irradiation, NCTD Gel responded to the tumor microenvironment(TME) and acted as an efficient Fenton reagent and photosensitizer, catalyzing the conversion of endogenous hydrogen peroxide(H_2O_2) within the tumor into oxygen(O_2), and hydroxyl radicals(·OH, type Ⅰ reactive oxygen species) and singlet oxygen(~1O_2, type Ⅱ reactive oxygen species), while depleting glutathione(GSH) to stabilize reactive oxygen species and alleviate tumor hypoxia. In vitro and in vivo experiments demonstrated that NCTD Gel exhibited significant CDT/PDT synergistic therapeutic effects. Further safety evaluation and metabolic testing confirmed its good biocompatibility and safety. This novel hydrogel is not only simple to prepare, safe, and cost-effective but also holds great potential for clinical transformation, providing insights and references for the research and development of metal ion-mediated hydrogel-based anti-tumor therapies.
