Study on method of "fraction-spectrum-effect-mechanism" for investigating traditional Chinese medicine prescriptions.
10.19540/j.cnki.cjcmm.20241017.601
- Author:
Yan-Tong XU
1
;
Ya-Nan TANG
2
Author Information
1. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
bioactive substance;
fraction-spectrum-effect-mechanism;
therapeutic mechanism;
traditional Chinese medicine prescription
- MeSH:
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Humans;
Drug Prescriptions
- From:
China Journal of Chinese Materia Medica
2025;50(3):840-845
- CountryChina
- Language:Chinese
-
Abstract:
Effective prescriptions are treasures of traditional Chinese medicine(TCM). To explore these resources and promote the features of TCM treatments, the core question is to investigate bioactive substances and therapeutic mechanisms of TCM prescriptions by modern science and technical methods. Currently, the bottleneck problem of studying TCM prescriptions is that the complicated components of TCM prescriptions hinder investigations on the therapeutic mechanisms of TCM prescriptions. To address this issue, a method of "fraction-spectrum-effect-mechanism" was proposed based on the essence, attribute, and characteristics of actions of TCM prescriptions, as well as the merits of currently available methods of chemical and pharmacodynamic studies of TCM prescription. The whole prescriptions were chosen as study objects. The bioactive substances and therapeutic mechanisms of TCM prescriptions were investigated by the systematical category of major constituents of TCM prescriptions. This method reflected the essence, attributes, and characteristics of actions of TCM prescriptions and showed comprehensiveness in theory. It also demonstrated feasibility in practices by using the molecular characteristics, physical and chemical properties, and separation methods of components of TCM prescriptions. This method provides a novel way to study TCM prescriptions, which could assist in studying on modern scientific connotation of TCM prescriptions and developing new drugs from effective TCM prescriptions.
