Proposal and research idea of "traditional Chinese medicine processing chemical biology".
10.19540/j.cnki.cjcmm.20241017.301
- Author:
Peng-Peng LIU
1
;
Qian CAI
1
;
Ji SHI
1
;
Nan XU
1
;
Hui GAO
1
;
Ke-Wu ZENG
2
;
Tian-Zhu JIA
1
Author Information
1. School of Pharmacy, Liaoning University of Traditional Chinese Medicine Dalian 116600, China Key Laboratory of Processing Technology and Principle, National Administration of Traditional Chinese Medicine Dalian 116600, China Technology Innovation Center for Traditional Chinese Medicine Processing of Liaoning Province Dalian 116600, China Traditional Chinese Medicine Processing Technology Inheritance Base of the National Administration of Traditional Chinese Medicine Dalian 116600, China.
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
processing of traditional Chinese medicine;
traditional Chinese medicine processing chemical biology(TCMPCB);
traditional Chinese medicine processing chemistry
- MeSH:
Drugs, Chinese Herbal/chemistry*;
Medicine, Chinese Traditional/methods*;
Humans;
Animals
- From:
China Journal of Chinese Materia Medica
2025;50(3):833-839
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM) processing is a unique and highly distinctive pharmaceutical technology in China. Utilizing modern scientific methods to elucidate the connotations of traditional processing theory and its effects is expected to facilitate the inheritance, development, innovation, and enhancement of TCM processing, and lead to more original research outcomes in the field of TCM. The breakthrough in TCM processing lies in the study of its underlying principles, and analyzing these principles involves researching the transformation mechanisms of chemical components and the biological effect mechanisms of the transformed components. This paper proposed the concept of "TCM processing chemical biology"(TCMPCB) for the first time. Under the guidance of TCM theory, the active components transformed during TCM processing were used as chemical tools to study their targets and molecular regulatory mechanisms, aiming to clarify the scientific principles by which TCM processing affected biological effects in the organism. The research findings also provided new directions for discovering novel active components, new lead compounds, creating new decoction pieces, and developing new TCM drugs. This paper provided a detailed introduction to the background, definition, research content, research ideas, research methods, and prospects of TCMPCB, with the aim of offering new research perspectives for analyzing the principles of TCM processing and providing new pathways for achieving the "four new and eight transformations" in TCM processing.
