Sesquiterpenoids from resin of Commiphora myrrha.
10.19540/j.cnki.cjcmm.20241224.201
- Author:
Hao HUANG
1
;
Ran WANG
1
;
Ya-Zhu YANG
1
;
Jiao-Jiao YIN
1
;
Yue LIN
1
;
Yun-Fang ZHAO
2
;
Hui-Xia HUO
2
;
Jun LI
3
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
2. Modern Research Center for Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
3. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Modern Research Center for Traditional Chinese Medicine, Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
anti-inflammatory activity;
guaiane;
resin of Commiphora myrrha;
sesquiterpenoid
- MeSH:
Commiphora/chemistry*;
Animals;
Mice;
Resins, Plant/chemistry*;
Sesquiterpenes/isolation & purification*;
Molecular Structure;
Nitric Oxide;
Macrophages/metabolism*;
RAW 264.7 Cells;
Drugs, Chinese Herbal/pharmacology*
- From:
China Journal of Chinese Materia Medica
2025;50(3):702-707
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of Commiphora myrrha was investigated by column chromatography on silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated by comprehensive spectroscopic methods including UV, IR, MS, NMR, as well as ECD calculation. Seven compounds were isolated from the dichloromethane-soluble fraction of C. myrrha and their structures were identified as(1S,2R,4S,5R,8S)-guaiane-2-hydroxy-7(11),10(15)-dien-6-oxo-12,8-olide(1), commipholide E(2), myrrhterpenoid H(3), myrrhterpenoid I(4), myrrhterpenoid E(5), 2α-methoxy-8α-hydroxy-6-oxogermacra-1(10),7(11)-dien-8,12-olide(6), 8,12-epoxy-1α,9α-hydroxy-eudesma-7,11-diene-6-dione(7). Compound 1 was a new compound and named myrrhterpenoid P. Compound 7 was isolated from Commiphora genus for the first time. Compounds 2, 5, and 6 significantly inhibited nitric oxide(NO) production in LPS-stimulated RAW264.7 cells, with IC_(50) values of(49.67±4.16),(40.80±1.27),(47.22±0.87) μmol·L~(-1), respectively [indomethacin as the positive control, with IC_(50) value of(63.92±2.60) μmol·L~(-1)].
