Research progress on dihydrochalcones from Lithocarpus litseifolius extracts in treatment of type 2 diabetes mellitus and its complications.
10.19540/j.cnki.cjcmm.20240827.701
- Author:
Yun-Qin WEI
1
;
Yu-Lan CAI
1
;
Yan YANG
1
;
Shang-Heng FAN
1
;
Lin-Li WU
1
;
Gui-Lan NIE
1
Author Information
1. the Second Affiliated Hospital of Zunyi Medical University Zunyi 563000, China.
- Publication Type:English Abstract
- Keywords:
Lithocarpus litseifolius;
complications;
dihydrochalcones;
phloretin;
phloridzin;
trilobatin;
type 2 diabetes mellitus
- MeSH:
Chalcones/chemistry*;
Diabetes Mellitus, Type 2/metabolism*;
Humans;
Animals;
Elaeocarpaceae/chemistry*;
Drugs, Chinese Herbal/therapeutic use*;
Hypoglycemic Agents/chemistry*;
Plant Extracts/chemistry*
- From:
China Journal of Chinese Materia Medica
2025;50(3):658-671
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus(T2DM) is a prevalent metabolic and endocrine disorder. Long-term hyperglycemia can lead to severe chronic complications, imposing substantial economic burdens on both society and patients. Despite the availability of various hypoglycemic agents for clinical use, these agents often fail to meet the therapeutic needs of T2DM and its complications. Consequently, there is an urgent need for novel therapeutic strategies and drugs. Lithocarpus litseifolius(L. litseifolius), commonly referred to as "cordyceps on trees", has a long history of use in traditional medicine and can be applied in tea, sugar, and medicine. Research indicates that L. litseifolius extracts are rich in dihydrochalcones, including trilobatin, phloridzin, and phloretin, which exhibit a range of pharmacological activities, such as anti-inflammatory, antioxidant, hypoglycemic, hypolipidemic, hepatoprotective, and cardioprotective effects. These properties suggest potential applications in the treatment of T2DM and its complications. This review systematically compiled and organized the relevant literature from the past decade on dihydrochalcones(trilobatin, phloridzin, and phloretin) from L. litseifolius extracts. It highlighted recent research progress regarding their role in treating T2DM and its complications through mechanisms such as reducing insulin resistance, regulating glucose transport, improving glucose and lipid metabolism, modulating enzyme activity, regulating gut microbiota, and alleviating inflammation and oxidative damage. The purpose of this review is to provide a reference and basis for future research on the prevention and treatment of T2DM and its complications using dihydrochalcones(trilobatin, phloridzin, and phloretin) from L. litseifolius extracts.
