Molecular mechanism of programmed cell death in lung cancer and progress in traditional Chinese medicine intervention.
10.19540/j.cnki.cjcmm.20241014.302
- Author:
Cheng LUO
1
;
Bo NING
2
;
Xin-Yue ZHANG
1
;
Yu-Zhi HUO
1
;
Xin-Hui WU
1
;
Yuan-Hang YE
3
;
Fei WANG
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072, China Chengdu University of Traditional Chinese Medicine Chengdu 610032, China.
2. Chengdu University of Traditional Chinese Medicine Chengdu 610032, China.
3. Pengzhou Third People's Hospital Chengdu 611931, China.
- Publication Type:English Abstract
- Keywords:
lung cancer;
molecular mechanism;
programmed cell death;
traditional Chinese medicine
- MeSH:
Humans;
Lung Neoplasms/pathology*;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/therapeutic use*;
Apoptosis/drug effects*;
Animals;
Autophagy/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(3):632-643
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most common and deadliest cancers globally, with its incidence and mortality rates rising each year. Therefore, finding new, safe, and effective alternative therapies poses a significant research challenge in this field. Programmed cell death refers to the process by which cells actively self-destruct in response to specific stimuli, regulated by genetic mechanisms. Modern research indicates that dysregulation of programmed cell death is widespread in the occurrence and progression of lung cancer, allowing cancer cells to evade death while continuing to proliferate and metastasize. Thus, inducing the death of lung cancer cells can be considered a novel therapeutic strategy for treating the disease. In recent years, research on traditional Chinese medicine(TCM) in the field of oncology has gained widespread attention, becoming a focal point. An increasing number of studies have demonstrated that TCM can inhibit the progression of lung cancer and exert anti-cancer effects by inducing apoptosis, necroptosis, pyroptosis, autophagy, and ferroptosis. This paper provided a comprehensive review of the molecular mechanisms of programmed cell death in lung cancer, along with the potential mechanisms and research advancements related to the regulation of these processes by TCM, so as to establish a theoretical foundation and direction for future basic and clinical research on lung cancer.
