Influence of iron metabolism on osteoporosis and modulating effect of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20240919.401
- Author:
Yi-Li ZHANG
1
;
Bao-Yu QI
2
;
Chuan-Rui SUN
2
;
Xiang-Yun GUO
1
;
Shuang-Jie YANG
3
;
Ping LIU
2
;
Xu WEI
2
Author Information
1. School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. Wangjing Hospital, China Academy of Chinese Medical Sciences Beijing 100102, China.
3. School of Public Health, Zhejiang University/Second Affiliated Hospital of Zhejiang University Hangzhou 310014, China.
- Publication Type:English Abstract
- Keywords:
bone metabolism;
ferroptosis;
iron metabolism;
osteoporosis;
traditional Chinese medicine
- MeSH:
Osteoporosis/drug therapy*;
Humans;
Iron/metabolism*;
Drugs, Chinese Herbal/pharmacology*;
Animals;
Medicine, Chinese Traditional;
Bone and Bones/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(3):575-582
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that an imbalance in iron metabolism can affect the composition and microstructural changes of bone, disrupting bone homeostasis and leading to osteoporosis(OP). The imbalance in iron metabolism, along with its induced local abnormal microenvironment and cellular iron death, has become a new focal point in OP research, drawing increasing attention from the academic community regarding the regulation of iron metabolism to prevent and manage OP. From the perspective of traditional Chinese medicine(TCM), iron metabolism imbalance has potential connections to TCM theories regarding internal organs, as well as treatments aimed at tonifying the kidney, strengthening the spleen, and activating blood circulation. Evidence is continually emerging that TCMs and effective components that tonify the kidney, strengthen the spleen, and activate blood circulation can prevent and manage OP by regulating iron metabolism. This article analyzes the relationship between iron and bone, as well as the effects of TCM formulations on improving iron metabolism and influencing bone metabolism, from the perspectives of iron metabolism mechanisms and TCM interventions, aiming to broaden existing clinical strategies for prevention and treatment and inject new momentum into the field of OP as it moves into a new era.
