Advances in role and mechanism of traditional Chinese medicine active ingredients in regulating balance of Th1/Th2 and Th17/Treg immune responses in asthma patients.
10.19540/j.cnki.cjcmm.20241010.301
- Author:
Ya-Sheng DENG
1
;
Lan-Hua XI
2
;
Yan-Ping FAN
1
;
Wen-Yue LI
1
;
Yong-Hui LIU
1
;
Zhao-Bing NI
1
;
Ming-Chan WEI
1
;
Jiang LIN
1
Author Information
1. School of Basic Medical Sciences, Guangxi University of Chinese Medicine Nanning 530200, China.
2. Hainan Traditional Chinese Medicine Hospital Haikou 570100, China.
- Publication Type:English Abstract
- Keywords:
Th1/Th2;
Th17/Treg;
asthma;
immune response balance;
mechanism of action;
research progress;
traditional Chinese medicine active ingredients
- MeSH:
Asthma/genetics*;
Humans;
Drugs, Chinese Herbal/chemistry*;
Th2 Cells/drug effects*;
Th17 Cells/drug effects*;
T-Lymphocytes, Regulatory/drug effects*;
Th1 Cells/drug effects*;
Animals;
Cytokines/immunology*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2025;50(4):1000-1021
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic inflammatory disease involving multiple inflammatory cells and cytokines. Its pathogenesis is complex, involving various cells and cytokines. Traditional Chinese medicine(TCM) theory suggests that the pathogenesis of asthma is closely related to the dysfunction of internal organs such as the lungs, spleen, and kidneys. In contrast, modern immunological studies have revealed the central role of T helper 1(Th1)/T helper 2(Th2) and T helper 17(Th17)/regulatory T(Treg) cellular immune imbalance in the pathogenesis of asthma. Th1/Th2 imbalance is manifested as hyperfunction of Th2 cells, which promotes the synthesis of immunoglobulin E(IgE) and the activation of eosinophil granulocytes, leading to airway hyperresponsiveness and inflammation.Meanwhile, Th17/Treg imbalance exacerbates the inflammatory response in the airways, further contributing to asthma pathology.Currently, therapeutic strategies for asthma are actively exploring potential targets for regulating the balance of Th1/Th2 and Th17/Treg immune responses. These targets include cytokines, transcription factors, key proteins, and non-coding RNAs. Precisely regulating the expression and function of these targets can effectively modulate the activation and differentiation of immune cells. In recent years,traditional Chinese medicine active ingredients have shown unique potential and prospects in the field of asthma treatment. Based on this, the present study systematically summarizes the efficacy and specific mechanisms of TCM active ingredients in treating asthma by regulating Th1/Th2 and Th17/Treg immune balance through literature review and analysis. These active ingredients, including flavonoids, terpenoids, polysaccharides, alkaloids, and phenolic acids, exert their effects through various mechanisms, such as inhibiting the activation of inflammatory cells, reducing the release of cytokines, and promoting the normal differentiation of immune cells. This study aims to provide a solid foundation for the widespread application and in-depth development of TCM in asthma treatment and to offer new ideas for clinical research and drug development of asthma.
