Exploration of biological essence of blood heat syndrome and mechanism of blood-cooling traditional Chinese medicine from combination of disease and syndrome.
10.19540/j.cnki.cjcmm.20241108.502
- Author:
Fei-Yue SUN
1
;
Zhi-Wei JING
2
;
Jin-Wen GE
3
;
Zhi-Gang MEI
1
Author Information
1. School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine Changsha 410208, China.
2. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
3. Hunan Academy of Chinese Medicine Changsha 410006, China.
- Publication Type:English Abstract
- Keywords:
biological essence;
blood heat syndrome;
blood-cooling traditional Chinese medicine;
combination of disease and syndrome;
inflammation
- MeSH:
Humans;
Medicine, Chinese Traditional/methods*;
Hyperthermia/diagnosis*;
Drugs, Chinese Herbal/therapeutic use*;
Syndrome
- From:
China Journal of Chinese Materia Medica
2025;50(4):985-993
- CountryChina
- Language:Chinese
-
Abstract:
Blood heat syndrome, one of the main subtypes of blood syndrome in traditional Chinese medicine(TCM), is mainly diagnosed by bleeding and heat manifestations and treated by the blood-cooling method. The biological essence of blood heat syndrome has not been elucidated yet, and there is a lack of systematic research on the potential mechanisms underlying the blood-cooling method. The biological essence of blood heat syndrome is closely related to abnormal immune response, oxidative stress, coagulation dysfunction, endocrine disorders, abnormalities in energy metabolism and so on. Blood heat syndrome is common in autoimmune skin diseases( such as systemic lupus erythematosus, psoriasis, and purpura), central hyperthermia, infectious diseases( such as infectious mononucleosis and COVID-19), and hemorrhagic diseases in gynecology. As the primary clinical therapy for blood heat syndrome, blood-cooling TCM is usually combined with the TCM with effects of activating blood and resolving stasis, nourishing Yin,and extinguishing wind to play the role of cooling blood. The mechanisms of above therapies may be attributed to reducing inflammation, inhibiting oxidative stress, restoring the balance of blood coagulation and metabolism, regulating the secretion of sex hormones, and alleviating allergic reactions. This article systematically explores the biological essence of blood heat syndrome and elucidates the targets and underlying mechanism of the blood-cooling method, laying a scientific foundation for the clinical application of TCM in the prevention and treatment of diseases associated with blood heat syndrome.
