Prediction of quality markers of Schisandrae Chinensis Fructus in treatment of bronchial asthma based on analytic hierarchy process-entropy weight method, fingerprint and network pharmacology.
10.19540/j.cnki.cjcmm.20241111.201
- Author:
Xiao-Hong YANG
1
;
Xue-Mei LAN
1
;
Hui-Juan XIE
2
;
Bin YANG
2
;
Rong-Ping YANG
3
;
Hua LI
2
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China Southwest University Chongqing 400715, China.
2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.
3. Southwest University Chongqing 400715, China.
- Publication Type:Journal Article
- Keywords:
Schisandrae Chinensis Fructus;
analytic hierarchy process-entropy weight method;
bronchial asthma;
fingerprint;
network pharmacology;
quality markers
- MeSH:
Schisandra/chemistry*;
Asthma/drug therapy*;
Drugs, Chinese Herbal/therapeutic use*;
Network Pharmacology;
Humans;
Entropy;
Lignans/analysis*;
Fruit/chemistry*;
Quality Control;
Cyclooctanes;
Polycyclic Compounds/analysis*
- From:
China Journal of Chinese Materia Medica
2025;50(4):974-984
- CountryChina
- Language:Chinese
-
Abstract:
In this study, potential quality markers(Q-markers) of Schisandrae Chinensis Fructus for treating bronchial asthma were predicted based on analytic hierarchy process(AHP), entropy weight method(EWM), fingerprint, and network pharmacology. AHPEWM was employed to quantitatively identify the Q-markers of Schisandrae Chinensis Fructus. AHP was used to weight the primary indicators(effectiveness, measurability, and specificity), while EWM was employed to analyze the secondary indicators of each primer indicator. Further, through fingerprint combined with network pharmacology, a ″component-target-pathway″ network was constructed to screen the components of Schisandrae Chinensis Fructus for treating bronchial asthma. It was finally determined that schisandrol A,schisandrin A, and schisandrin B were potential Q-markers of Schisandrae Chinensis Fructus in the treatment of bronchial asthma. This study is the first to comprehensively use AHP-EWM, fingerprint, and network pharmacology to screen the key Q-markers of Schisandrae Chinensis Fructus in the treatment of bronchial asthma. This study provides a scientific basis for improving the quality standard of Schisandrae Chinensis Fructus and lays a foundation for studying its material basis in treating bronchial asthma.
