Research progress on chemical constituents, pharmacological effects of Anemarrhenae Rhizoma and predictive analysis of its quality markers.
10.19540/j.cnki.cjcmm.20241211.201
- Author:
Wen-Jun WANG
1
;
Ze-Min YANG
1
;
An LIU
2
;
Li-Dong SHAO
3
;
Jin-Tang CHENG
2
Author Information
1. School of Chinese Materia Medica, Yunnan University of Chinese Medicine Kunming 650500, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.
2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.
3. School of Chinese Materia Medica, Yunnan University of Chinese Medicine Kunming 650500, China.
- Publication Type:English Abstract
- Keywords:
Anemarrhenae Rhizoma;
chemical constituent;
compound prescription;
pharmacological effect;
quality marker
- MeSH:
Anemarrhena/chemistry*;
Drugs, Chinese Herbal/pharmacology*;
Rhizome/chemistry*;
Humans;
Animals;
Quality Control
- From:
China Journal of Chinese Materia Medica
2025;50(4):934-945
- CountryChina
- Language:Chinese
-
Abstract:
Anemarrhenae Rhizoma is bitter, sweet, and cold in nature, and has the effects of clearing heat, dispelling fire, nourishing Yin, and moisturizing dryness. It is associated with the lung, stomach, and kidney meridians, and is mainly distributed in the northwestern and northern regions of China. Modern research has shown that Anemarrhenae Rhizoma contains various chemical active constituents, including steroidal saponins, flavonoids, polysaccharides, lignans, volatile oils, and alkaloids. These constituents exhibit pharmacological effects such as anti-tumor, hypoglycemic, anti-inflammatory, and neuroprotective activities. However, there have been few comprehensive summaries of Anemarrhenae Rhizoma in recent years, which has limited its in-depth research and development. The complexity of traditional Chinese medicine constituents, along with their quality and efficacy, is easily influenced by processing, preparation, and the growing environment and resource distribution. This paper summarizes the resources, chemical constituents, and pharmacological effects of Anemarrhenae Rhizoma, and predicts its quality markers(Q-markers) from several aspects, including the specificity of chemical composition, properties related to preparation and active ingredients, measurability of chemical components, compounding environment, construction of the ″active ingredient-target″ network pathway, and differences in active ingredient content from different origins and parts. These predicted Q-markers may provide a basis for improving the quality evaluation system of Anemarrhenae Rhizoma.
