Research progress on chemical constituents, pharmacological effects of Rubi Fructus and predictive analysis of its quality markers.
10.19540/j.cnki.cjcmm.20241202.201
- Author:
Bao-Song LIU
1
;
Er-Wei YU
1
;
Ying-Ying SUN
2
;
Yao-Yu SONG
2
;
Ke-Han JIANG
2
;
Ya-Gang SONG
3
;
Ming-San MIAO
3
;
Meng-Fan PENG
4
Author Information
1. Preparation Room of Zhumadian Traditional Chinese Medicine Hospital Zhumadian 463000, China.
2. School of Medicine, Huanghuai University Zhumadian 463000, China.
3. NMPA Key Laboratory for Safety Research and Evaluation of Traditional Chinese Medicine, Henan University of Chinese Medicine Zhengzhou 450046, China.
4. School of Medicine, Huanghuai University Zhumadian 463000, China NMPA Key Laboratory for Safety Research and Evaluation of Traditional Chinese Medicine, Henan University of Chinese Medicine Zhengzhou 450046, China.
- Publication Type:English Abstract
- Keywords:
Rubi Fructus;
chemical constituent;
pharmacological effect;
quality marker
- MeSH:
Drugs, Chinese Herbal/pharmacology*;
Humans;
Rubus/chemistry*;
Fruit/chemistry*;
Quality Control;
Animals
- From:
China Journal of Chinese Materia Medica
2025;50(4):922-933
- CountryChina
- Language:Chinese
-
Abstract:
Rubi Fructus has a long history of medicinal and edible use in China. It contains chemical components such as terpenes, flavonoids, phenolic acids, fatty acids, and alkaloids, and possesses various pharmacological activities, including antioxidant, anti-inflammatory, hypoglycemic, anti-tumor, anti-osteoporosis, and liver-protective effects. Rubi Fructus is widely applied in medical, health, and food fields. The quality of Rubi Fructus can directly affect the safety and effectiveness of clinical medication. Therefore, this article reviews the research progress on the chemical constituents and pharmacological effects of Rubi Fructus. Based on the concept of traditional Chinese medicine(TCM) quality markers(Q-markers), the article explores the screening and determination of Q-markers for Rubi Fructus from various aspects, including plant kinship, traditional efficacy, medicinal properties, measurability of chemical composition, different processing methods, producing areas, harvesting periods, and planting conditions. The components ellagic acid, kaempferol, quercetin, kaempferol-3-O-rutinoside, rutin, astragalin, tiliroside, and hyperoside are preliminarily proposed as Q-markers for Rubi Fructus, providing a reference for the quality control of Rubi Fructus.
