New strategy and method in traditional Chinese medicine compatibility for detoxification based on component-target-effect interaction.
10.19540/j.cnki.cjcmm.20241025.601
- Author:
Zhao-Fang BAI
1
;
Wei SHI
2
;
Yuan GAO
3
;
Jia-Bo WANG
3
;
Xiao-He XIAO
4
Author Information
1. Military Institute of Chinese Materia, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing 100700, China.
2. Military Institute of Chinese Materia, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China School of Traditional Chinese Medicine, Capital Medical University Beijing 100069, China.
3. School of Traditional Chinese Medicine, Capital Medical University Beijing 100069, China.
4. Military Institute of Chinese Materia, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China Department of Hepatology, Fifth Medical Center of Chinese PLA General Hospital Beijing 100039, China.
- Publication Type:Journal Article
- Keywords:
compatibility for detoxification;
component-target-effect interaction;
safe and precise use of TCM;
toxicity of traditional Chinese medicine(TCM)
- MeSH:
Drugs, Chinese Herbal/chemistry*;
Humans;
Medicine, Chinese Traditional/methods*;
Animals;
Drug-Related Side Effects and Adverse Reactions/prevention & control*
- From:
China Journal of Chinese Materia Medica
2025;50(4):853-859
- CountryChina
- Language:Chinese
-
Abstract:
The safety of traditional Chinese medicine(TCM) has always been taken very seriously, and rich and valuable theories and experiences have been developed to ensure the safe and precise use of TCM in clinical practices. In recent years, the cognitive theory of toxicity of TCM, has undergone a profound change. TCM is characterized by the existence of intrinsic toxicity, idiosyncratic toxicity, and indirect toxicity related to organic factors. Therefore, the traditional theories and experiences of TCM, which focus on the prevention and control of intrinsic toxicity, fail to be used for the development of risk prevention and control countermeasures for newly discovered TCM with idiosyncratic toxicity and indirect toxicity. Accordingly, based on the toxicity classification and mechanism characteristics of TCM, this paper proposed a new strategy and method in TCM compatibility for detoxification based on componenttarget-effect interaction. The strategy based on component-target-effect interaction is to carry out TCM compatibility for detoxification by blocking the occurrence of drug-mediated damage and promoting damage repair through component interactions, target interactions,and/or effect interactions. Based on this theory, the paper established a strategy for TCM compatibility that aligned with the cognitive theory of toxicity of TCM, so as to achieve safe and precise use of TCM in clinical practices. The strategy based on component-targeteffect interaction has been exemplarily applied to the development of countermeasures to reduce the toxicity of TCM, including Polygonum Multiflorum, Epimedii Folium, and Psoraleae Fructus, and a new mechanism of Glycyrrhizae Radix et Rhizoma to " harmonize various medicines and detoxify myriad poisons" was illustrated, providing a scientific basis for the safe and precise use of TCM in clinical practice. This paper explained the scientific connotation, application forms, and application examples of componenttarget-effect interaction, aiming to provide a theoretical and methodological basis for guaranteeing the precise use of TCM in clinical practice and innovate the theories and methods of TCM compatibility for detoxification.
