A new tetralone glycoside in leaves of Cyclocarya paliurus.
10.19540/j.cnki.cjcmm.20241101.201
- Author:
Ting-Si GUO
1
;
Qin HUANG
1
;
Qi-Qi HU
1
;
Fei-Bing HUANG
1
;
Qing-Ling XIE
1
;
Han-Wen YUAN
1
;
Wei WANG
1
;
Yu-Qing JIAN
1
Author Information
1. Traditional Chinese Medicine and Ethnomedicine Innovation & Development International Laboratory,Hunan University of Chinese Medicine Changsha 410208, China.
- Publication Type:Journal Article
- Keywords:
antioxidant activity;
chemical constituents;
leaves of Cyclocarya paliurus;
tetralone glycoside
- MeSH:
Plant Leaves/chemistry*;
Glycosides/isolation & purification*;
Juglandaceae/chemistry*;
Tetralones/isolation & purification*;
Drugs, Chinese Herbal/isolation & purification*
- From:
China Journal of Chinese Materia Medica
2025;50(1):146-167
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from leaves of Cyclocarya paliurus were isolated and purified by chromatography on silica gel, C_(18) reverse-phase silica gel, and Sephadex LH-20 gel, as well as semi-preparative high-performance liquid chromatography. Six compounds were identified by UV, IR, NMR, MS, calculated ECD, and comparison with literature data as cyclopaloside D(1), boscialin(2),(5R,6S)-6-hydroxy-6-[(E)-3-hydroxybut-1-enyl]-1,1,5-trimethylcyclohexanone(3), 3S,5R-dihydroxy-6R,7-megastigmadien-9-one(4), 3S,5R-dihydroxy-6S,7-megastigmadien-9-one(5), and gingerglycolipid A(6), respectively. Among them, compound 1 was identified as a new tetralone glycoside, and compounds 2-6 were isolated from leaves of C. paliurus for the first time. Furthermore, compound 1 exhibited strong antioxidant activity, with the IC_(50) of(454.20±31.81)μmol·L~(-1) and(881.82±42.31)μmol·L~(-1) in scavenging DPPH and ABTS free radicals, respectively.
