Research progress on mechanism of traditional Chinese medicine in regulating neutrophil extracellular traps in prevention and treatment of metabolic diseases.
10.19540/j.cnki.cjcmm.20241021.301
- Author:
Sai ZHANG
1
;
Ming-Yuan FAN
1
;
Jiu-Shu YUAN
1
;
Qi-Yuan YAO
1
;
Hong-Yan XIE
1
;
Hai-Po YUAN
1
;
Hong GAO
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072, China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu 610075, China.
- Publication Type:English Abstract
- Keywords:
metabolic disease;
neutrophil extracellular traps;
research progress;
spleen heat;
traditional Chinese medicine;
turbid toxin
- MeSH:
Humans;
Extracellular Traps/metabolism*;
Metabolic Diseases/metabolism*;
Drugs, Chinese Herbal/therapeutic use*;
Animals;
Neutrophils/metabolism*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2025;50(1):78-93
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic diseases have seen a steady increase in incidence in recent years, becoming one of the main causes of sub-health status globally. Neutrophil extracellular traps(NETs) are reticular complexes containing DNA, which trap foreign microorganisms or induce an immune response. Current research indicates that NETs are widely active in various metabolic diseases and can cause severe damage to the body through multiple mechanisms, including promoting blood glucose elevation, damaging vascular endothelial cells, forming vascular embolisms, triggering intense inflammation, and promoting lipid accumulation. Therefore, intervening in NETs is an important approach to treating metabolic diseases. Research has shown a close relationship between the theory of spleen heat-turbid toxin theory and metabolic diseases-NETs mechanism. The basic pathogenesis include the internal accumulation of phlegm-dampness, qi stagnation and blood stasis, internal accumulation of dampness-heat, phlegm and blood stasis, and flourishing toxic heat. Various Chinese herbal medicines with the functions of dispelling dampness, resolving phlegm, promoting blood circulation to remove blood stasis, and clearing heat and toxins, along with their extracts and compound prescriptions, can treat metabolic diseases by regulating NETs and delaying disease progression. This paper systematically outlined the formation mechanisms of NETs, their connection to metabolic diseases, the theoretical basis in TCM, their roles in numerous metabolic diseases, and the current research status of TCM in regulating NETs to prevent and control metabolic diseases, aiming to provide effective reference ideas for developing therapeutic strategies for metabolic diseases.
