Research progress on transcription factors and regulatory proteins of Salvia miltiorrhiza.
10.19540/j.cnki.cjcmm.20241014.104
- Author:
Wen XU
1
;
Mei TIAN
1
;
Ye SHEN
1
;
Juan GUO
1
;
Bao-Long JIN
1
;
Guang-Hong CUI
1
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:English Abstract
- Keywords:
Salvia miltiorrhiza;
regulatory protein;
transcription factor
- MeSH:
Salvia miltiorrhiza/chemistry*;
Plant Proteins/metabolism*;
Gene Expression Regulation, Plant;
Transcription Factors/metabolism*;
Abietanes/metabolism*
- From:
China Journal of Chinese Materia Medica
2025;50(1):58-70
- CountryChina
- Language:Chinese
-
Abstract:
Salvia miltiorrhiza is a perennial herb of the genus Salvia(Lamiaceae). As one of the earliest medicinal plants to undergo molecular biology research, it has gradually become a model plant for molecular biology of medicinal plants. With the gradual analysis of the genome of S. miltiorrhiza and the biosynthetic pathways of its main active components tanshinone and salvianolic acids, the transcriptional regulation mediated by transcription factors and related regulatory proteins has gradually become a new research focus. Due to the lack of scientific and unified naming of transcription factors and different research indexes in different literature, this paper systematically sorted out the transcription factors in different literature with the genomes of DSS3 from selfing for three generations and bh2-7 from selfing for six generations as reference. In total, 73 transcription factors and related regulatory proteins belonging to 13 gene families were identified. The effects of overexpression or gene silencing experiments on tanshinone and salvianolic acids were also analyzed. This study unified the identified transcription factors, which laid a foundation for further constructing the regulatory networks of secondary metabolites and insect or stress resistance and improving the quality of medicinal materials by using global transcriptional regulation engineering.
