Research progress in mechanisms of traditional Chinese medicine polysaccharides in prevention and treatment of alcoholic liver disease.
10.19540/j.cnki.cjcmm.20240928.601
- Author:
Yu-Fan CHEN
1
;
He JIANG
2
;
Qing MA
3
;
Qi-Han LUO
4
;
Shuo HUANG
4
;
Jiang QIU
5
;
Fu-Zhe CHEN
5
;
Zi-Yi SHAN
2
;
Ping QIU
5
Author Information
1. the Second School of Clinical Medicine, Zhejiang Chinese Medical University Hangzhou 310053, China School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
2. the Second School of Clinical Medicine, Zhejiang Chinese Medical University Hangzhou 310053, China.
3. the First School of Clinical Medicine, Zhejiang Chinese Medical University Hangzhou 310053, China.
4. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
5. School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.
- Publication Type:English Abstract
- Keywords:
alcoholic liver disease;
gut-liver axis;
lipid metabolism;
oxidative stress;
programmed cell death;
traditional Chinese medicine polysaccharides
- MeSH:
Humans;
Liver Diseases, Alcoholic/metabolism*;
Polysaccharides/administration & dosage*;
Drugs, Chinese Herbal/administration & dosage*;
Animals;
Oxidative Stress/drug effects*;
Medicine, Chinese Traditional;
Gastrointestinal Microbiome/drug effects*;
Lipid Metabolism/drug effects*
- From:
China Journal of Chinese Materia Medica
2025;50(2):356-362
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic liver disease(ALD), a major cause of chronic liver disease worldwide, poses a serious threat to human health. Despite the availability of various drugs for treating ALD, their efficacy is often uncertain, necessitating the search for new therapeutic approaches. Traditional Chinese medicine polysaccharides have garnered increasing attention in recent years due to their versatility, high efficiency, and low side effects, and they have demonstrated significant potential in preventing and treating ALD. Emerging studies have suggested that these polysaccharides exert their therapeutic effects through multiple mechanisms, including the inhibition of oxidative stress and the regulation of lipid metabolism, gut microbiota, and programmed cell death. This review summarizes the recent research progress in the pharmacological effects and regulatory mechanisms of traditional Chinese medicine polysaccharides in treating ALD, aiming to provide a scientific basis and theoretical support for their application in the prevention and treatment of ALD.
