A new nortriterpenoid from mastic.
10.19540/j.cnki.cjcmm.20240910.202
- Author:
Xue-Rui AN
1
;
Ya-Ping FENG
1
;
Yu-Wei SUN
1
;
Xin YANG
1
;
Wei LIU
1
;
Tao YUAN
2
Author Information
1. Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources,School of Chemistry and Chemical Engineering, Yili Normal University Yining 835000, China.
2. Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources,School of Chemistry and Chemical Engineering, Yili Normal University Yining 835000, China School of Health, Jiangxi Normal University Nanchang 330022, China.
- Publication Type:Journal Article
- Keywords:
anti-colorectal cancer;
anti-inflammatory;
chemical constituents;
mastic;
nortriterpenoid
- MeSH:
Mice;
Animals;
Mastic Resin/chemistry*;
Humans;
Macrophages/metabolism*;
Triterpenes/isolation & purification*;
Nitric Oxide;
Molecular Structure;
RAW 264.7 Cells;
Drugs, Chinese Herbal/isolation & purification*
- From:
China Journal of Chinese Materia Medica
2024;49(23):6342-6351
- CountryChina
- Language:Chinese
-
Abstract:
Ten compounds were separated by various modern chromatographic methods from mastic. They were identified by HR-ESI-MS, IR, UV, NMR, quantum chemical calculation of NMR(qcc-NMR) and comparison with reported data in literature as 17β-hydroxy-28-norolean-18-en-3-one(1), 28-norolean-12,17-dien-3,11-dione(2), 28-norolean-16,18-dien-3-one(3),(24Z)-26-hydroxy-7,24-dientirucalla-3-one(4), masticadienonic acid(5)、masticadienolic acid(6)、erythrodiol(7), 3β,28-dihydroxyoleana-11,13(18)-diene(8), 3-oxo-olean-9(11),12-dien-28-oic acid(9), and 12-oleane-3,11-dione(10). Among them, compound 1 was a novel compound and compound 2 was a novel natural product. Compounds 1-2, 4, and 7-9 were isolated from mastic for the first time. Compound 1 significantly inhibited lipopolysaccharide-induced production of nitric oxide in mouse monocyte macrophage RAW264.7 cells with the IC_(50) of(7.44±0.49) μmol·L~(-1), which was more potent than the positive control, dexamethasone \[IC_(50)=(9.93±1.17) μmol·L~(-1)\]. Compounds 2-3, 5, and 9-10 also showed inhibitory effects, with the IC_(50) ranging from 14.82 to 28.82 μmol·L~(-1). Compounds 4-5, and 7 markedly inhibited the growth of human colon adenocarcinoma cells SW480, with the IC_(50) of(16.13±1.69),(27.40±1.81), and(10.01±0.10) μmol·L~(-1), respectively.
