Mechanism of traditional Chinese medicine in treating vascular calcification in chronic kidney disease based on BMP and SIRT signaling pathways.
10.19540/j.cnki.cjcmm.20240918.603
- Author:
Tian-Hao SUN
1
;
Wen ZHANG
1
;
Jing LI
1
;
Yu-Xin SUN
1
;
Hong-Shuo DONG
1
;
Hong-Tao YANG
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381,China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381,China.
- Publication Type:English Abstract
- Keywords:
bone morphogenetic proteins;
chronic kidney disease;
silence information regulator;
traditional Chinese medicine;
vascular calcification
- MeSH:
Humans;
Vascular Calcification/genetics*;
Renal Insufficiency, Chronic/genetics*;
Signal Transduction/drug effects*;
Bone Morphogenetic Proteins/genetics*;
Drugs, Chinese Herbal/therapeutic use*;
Animals;
Sirtuins/genetics*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2024;49(23):6302-6310
- CountryChina
- Language:Chinese
-
Abstract:
Vascular calcification significantly increases the incidence of cardiovascular disease and all-cause mortality patients with chronic kidney disease(CKD), severely affecting their health and lifespan. However, the mechanisms underlying vascular calcification in CKD remain incompletely understood, and the available therapeutic agents are limited. Research has found that the transformation of vascular smooth muscle cells(VSMCs) from a contractile phenotype to an osteoblast-like phenotype is a key step in CKD-related vascular calcification. As research on the pathogenesis of calcification progresses, it has been demonstrated that bone morphogenetic protein(BMP) and silent information regulator(SIRT) signaling pathways can participate in the process of vascular calcification by regulating the osteogenic transdifferentiation of VSMCs. Traditional Chinese medicine(TCM) has accumulated a wealth of valuable experience in the prevention and treatment of kidney diseases over centuries. Modern research indicates that TCM, with its multi-pathway, multi-target, and low-toxicity properties, has shown certain advantages in the prevention and treatment of CKD-related vascular calcification and in improving patients' quality of life. Therefore, in this study, we will introduce the latest research progress of TCM in preventing and treating CKD-related vascular calcification, particularly focusing on the BMP and SIRT signaling pathways, with the aim of providing ideas for the clinical diagnosis and treatment of CKD-related vascular calcification with TCM and related basic research.
