Advances in pharmacological mechanism and toxicology of gambogic acid.
10.19540/j.cnki.cjcmm.20240918.602
- Author:
Ke-Rong TU
1
;
Shang-Qin YANG
2
;
Qi-Qi XU
1
;
Liang-Liang LYU
2
;
Xian-Mei JIANG
1
;
Yao QI
1
;
Huan-Huan DING
3
;
Hong-Mei LIU
1
;
Lu-Lu CAI
1
;
Qiang SUN
1
Author Information
1. Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu 610072,China Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China Chengdu 610072, China.
2. School of Pharmacy, Southwest Medical University Luzhou 646000, China.
3. School of Life Science and Engineering, Southwest Jiaotong University Chengdu 610031, China.
- Publication Type:English Abstract
- Keywords:
gambogic acid;
molecular mechanism;
pharmacological activity;
toxicology
- MeSH:
Xanthones/toxicity*;
Humans;
Animals;
Drugs, Chinese Herbal/toxicity*;
Garcinia/chemistry*
- From:
China Journal of Chinese Materia Medica
2024;49(24):6593-6603
- CountryChina
- Language:Chinese
-
Abstract:
Gambogic acid, a caged xanthone compound derived from Garcinia, has been proven to be an important substance basis for the pharmacological effects of the plant. In recent years, it has received continuous attention due to its broad and significant pharmacological activities. Modern pharmacological investigations have demonstrated that gambogic acid endows various therapeutic effects such as anti-inflammatory, antioxidant, and anti-tumor activities, as well as benefits in retinopathy, organ protection, anti-microbial infection, bone protection, and neuropathic pain relief. Nevertheless, there is currently a lack of systematic summary and integration of the pharmacological effects and mechanisms of gambogic acid, which is critical for advancing the clinical application of this natural product. In addition, current research has raised concerns about potential safety risks associated with gambogic acid, such as organ toxicity, developmental toxicity, and hemolysis. Given this, this paper systematically reviewed and summarized the pharmacological effects, mechanisms, and toxicological profiles of gambogic acid, aiming to provide reference and data support for its clinical translation.
