Determination of physical properties and calibration of discrete element simulation parameters for Jianwei Xiaoshi Granules.
10.19540/j.cnki.cjcmm.20240924.301
- Author:
Zi-Qian WANG
1
;
Fan WU
2
;
Zhi-Jian ZHONG
3
;
Xiao-Rong LUO
3
;
Xin-Hao WAN
4
;
Jia-Li LIAO
4
;
Qing TAO
4
;
Zhen-Feng WU
5
Author Information
1. Key Laboratory of Modern Preparations of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China Jiangxi Drug Inspection Center Nanchang 330000, China.
2. Jiangxi Drug Inspection Center Nanchang 330000, China.
3. China Resources Jiangzhong Pharmaceutical Group Co., Ltd. Nanchang 330096, China.
4. Key Laboratory of Modern Preparations of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
5. Key Laboratory of Modern Preparations of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China National Key Laboratory of Creation of Modern Chinese Medicine with Classical Formulas Nanchang 330004, China Jiangxi Technology Innovation Center of Green Manufacturing of Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Jianwei Xiaoshi Granules;
calibration;
discrete element;
optimization;
repose angle;
simulation parameters
- MeSH:
Drugs, Chinese Herbal/chemistry*;
Calibration;
Computer Simulation
- From:
China Journal of Chinese Materia Medica
2024;49(24):6558-6564
- CountryChina
- Language:Chinese
-
Abstract:
The construction method and simulation parameter settings for the discrete element model of Jianwei Xiaoshi Granules, as the primary material of Jianwei Xiaoshi Tablets, are not yet clear. The accuracy of the simulation model significantly influences the dynamic response characteristics between granules. Therefore, it is necessary to calibrate the parameters to improve the accuracy of the simulation parameters. Using the repose angle of Jianwei Xiaoshi Granules as the response value, the response surface methodology was employed to optimize and calibrate the discrete element parameters. Physical experiments were conducted to determine the physical properties of Jianwei Xiaoshi Granules. Based on the Hertz-Mindlin with Johnson-Kendall-Roberts(JKR) V2 model and virtual simulation methods, a repose angle determination model was constructed in EDEM software. The repose angle was measured using image analysis and numerical fitting methods. The Plackett-Burman experiment was used to screen the initial parameters for significance in the discrete element simulation. The significant parameters were then subjected to a steepest ascent experiment to determine the optimal parameter range. Furthermore, based on the Box-Behnken experiment, a second-order regression equation between significant parameters and repose angle was established, with the repose angle of 37.64° in the physical experiment as the target value. The regression equation was optimized and solved. The significance screening experiment revealed that the granule-granule static friction coefficient, granule-granule rolling friction, and granule-steel plate rolling friction of Jianwei Xiaoshi Granules significantly influenced the simulated repose angle. The optimal parameter combination was found to be 0.330, 0.222, and 0.229. The simulation results with this optimal parameter combination showed that there was no significant difference between the simulated repose angle and the repose angle obtained in the physical experiment, with a relative error of 0.05%, which further validated the reliability of the calibrated discrete element parameters for Jianwei Xiaoshi Granules.
