Latent class analysis of therapeutic effects of Huoxiang Zhengqi Oral Liquid on patients with cold due to wind-cold and dampness stagnation.
10.19540/j.cnki.cjcmm.20240808.501
- Author:
Miao WU
1
;
Shi-Sui LUO
2
;
Jin YIN
1
;
Si-Cen JIN
2
;
Lin SUN
1
;
Hao-Qi ZHOU
3
;
Xin-Ting HUANG
1
;
Xiao-Hua ZHOU
4
Author Information
1. Chongqing Research Institute of Big Data, Peking University Chongqing 400039, China.
2. Taiji Group Co., Ltd. Chongqing 401123, China.
3. Department of Biostatistics, School of Public Health, Peking University Beijing 100191, China.
4. Chongqing Research Institute of Big Data, Peking University Chongqing 400039, China Department of Biostatistics, School of Public Health, Peking University Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Huoxiang Zhengqi Oral Liquid;
doubly robust estimation;
latent class analysis;
wind-cold and dampness stagnation
- MeSH:
Humans;
Male;
Female;
Drugs, Chinese Herbal/therapeutic use*;
Middle Aged;
Adult;
Young Adult;
Aged;
Adolescent;
Administration, Oral;
Wind;
Child;
Spleen/drug effects*;
Cold Temperature;
Aged, 80 and over
- From:
China Journal of Chinese Materia Medica
2024;49(21):5944-5950
- CountryChina
- Language:Chinese
-
Abstract:
The demographic characteristics, drug use, clinical symptoms and other data of the patients treated with Huoxiang Zhengqi Oral Liquid were collected. The latent class analysis(LCA) was performed to reveal the distribution of primary symptoms, and then the doubly robust estimation was employed to analyze the efficacy of different doses of Huoxiang Zhengqi Oral Liquid in different populations. A total of 11 273 patients were enrolled in this study, including 4 347 males and 6 926 females. A total of 15 primary symptoms were included, with the top 3 being dizziness(53.9%), head heaviness(39.6%), and nausea(39.4%). According to the LCA, the population was divided into 3 groups of spleen deficiency and dampness exuberance(5 604 cases, 49.71%), upward harassing of wind-phlegm(4 955 cases, 43.96%), and spleen Qi deficiency(714 cases, 6.33%). Double robust estimation showed that the time to recovery of the patients with spleen Qi deficiency had no significant difference regarding the daily dose. Compared with the daily dose of 20 mL, the daily doses of 40, and 60 mL shortened the time to recovery by 16.67(95%CI[5.23, 28.12]) and 15.94 h(95%C1[7.45, 24.43]) in the patients with upward harassingof wind-phlegm, the daily doses of 30, 40, and 60 mL shortened the time to recovery by 4.42(95%CI[1.06, 7.77]), 13.07(95%CI[1.61, 24.54]), 13.92 h(95%CI[5.14, 22.70]) in the patients with spleen deficiency and dampness exuberance, respectively. The patients with cold due to wind-cold and dampness stagnation had more primary syndromes, and the disease locations were mainly in the head, stomach, and spleen. In clinical practice, the daily dose of Huoxiang Zhengqi Oral Liquid can be increased according to the symptoms of patients, which can shorten the time to recovery.
