One new galloyl derivative from Isodon henryi.
10.19540/j.cnki.cjcmm.20240806.201
- Author:
Yi-Xiao LI
1
;
Jun CHI
1
;
Zhi-Min WANG
2
;
Li-Ping DAI
1
Author Information
1. Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine Zhengzhou 450046, China.
2. National Engineering Laboratory of Traditional Chinese Medicine Quality Control Technology, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Isodon henryi;
anti-inflammatory activity;
chemical constituents;
galloyl derivative
- MeSH:
Mice;
Animals;
RAW 264.7 Cells;
Nitric Oxide/metabolism*;
Isodon/chemistry*;
Molecular Structure;
Drugs, Chinese Herbal/chemistry*;
Macrophages/drug effects*;
Magnetic Resonance Spectroscopy;
Gallic Acid/analogs & derivatives*
- From:
China Journal of Chinese Materia Medica
2024;49(21):5909-5913
- CountryChina
- Language:Chinese
-
Abstract:
Seven compounds(1-7) were isolated from Isodon henryi through silica gel, Sephadex LH-20, ODS, MCI column chromatography and semi-preparative HPLC. Their structures were identified as isogallicacid(1), caffeic acid(2), syringic acid(3), protocatechuic acid(4), oresbiusin A(5), lophanthoside A(6), and 8-hydroxypinoresinol(7), by spectroscopic techniques including HR-MS, IR, UV, NMR, and ECD. Compound 1 was a new galloyl derivative. Moreover, it demonstrated a significant inhibitory effect on the lipopolysaccharide-induced release of nitric oxide from RAW264.7 cells.
