Two new α-carbonylamides from Corydalis Rhizoma.
10.19540/j.cnki.cjcmm.20240805.201
- Author:
Yue-Lin JIA
1
;
Ling-Yan WANG
2
;
Xiao-Hong WEI
2
;
Huan XIA
2
;
Li-Xia CHEN
3
;
Gui-Yang XIA
4
;
Sheng LIN
5
Author Information
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China Wuya Innovation College, Shenyang Pharmaceutical University Shenyang 110016, China.
2. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China.
3. Wuya Innovation College, Shenyang Pharmaceutical University Shenyang 110016, China.
4. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China College of Ecol-Environmental Engineering, Qinghai University Xining 810016, China.
5. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China College of Pharmacy, Qinghai Minzu University Xining 810007, China.
- Publication Type:Journal Article
- Keywords:
Corydalis Rhizoma;
chemical constituent;
α-carbonylamides
- MeSH:
Corydalis/chemistry*;
Rhizome/chemistry*;
Drugs, Chinese Herbal/chemistry*;
Molecular Structure;
Amides/chemistry*;
Magnetic Resonance Spectroscopy;
Chromatography, High Pressure Liquid;
Alkaloids/chemistry*
- From:
China Journal of Chinese Materia Medica
2024;49(21):5898-5908
- CountryChina
- Language:Chinese
-
Abstract:
Corydalis Rhizoma is a commonly used traditional Chinese medicine(TCM) for regulating Qi and relieving pain in clinical practice, with remarkable efficacy. However, its pharmacodynamic substances are not yet fully understood and require further research. In this study, 24 compounds were isolated and identified from the aqueous extracts of vinegar-processed Corydalis Rhizoma using techniques such as macroporous adsorption resin column chromatography, Sephadex LH-20 column chromatography, and semi-preparative high-performance liquid chromatography. Their structures were determined based on their physicochemical properties and spectroscopic methods, including UV, IR, HR-MS, 1D NMR, and 2D NMR. Among these, compounds 1 and 2 are two rare natural α-carbonamide alkaloids, named yanhuoxamide A(compound 1) and yanhuoxamide B(compound 2), respectively. Compounds 3-24 are known compounds, identified as xanthoplanine(3), stigmast-4-ene-3,6-dione(4), norchelerythrine(5), ethyl ferulate(6), 6-hydroxymethyl-3-pyridinol(7), 6-(\[1,3\]dioxolo\[4,5-g\]isoquinoline-5-carbonyl)-2,3-dimethoxy-benzoic acid methyl ester(8), 1H-indole-3-carbaldehyde(9), 4-hydroxy-3-methoxy ethyl cinnamate(10), berberal(11), oblongine trifluoroacetate(12), thalbaicalidine(13), cyclopiamide(14), nicotinamide(15), dehydrocorypalline trifluoroacetate(16), 6-acetonyldihydrochelerythrine(17), 6-acetonyldihydrosanguinarine(18), norsanguinarine(19), oxysanguinarine(20), bulbocapnine(21), corydine(22),(-)-(13aS)-stylopine(23), and(-)-(9S,13S)-pallidine(24). Among these, compounds 3-15 were isolated from the genus Corydalis for the first time, and compounds 16-24 were isolated from Corydalis Rhizoma for the first time. Additionally, the inhibitory activity of compounds 1 and 2 on acetylcholinesterase(AChE) was evaluated.
