Anti-tumor mechanism of traditional Chinese medicine via Hedgehog signaling pathway: a review.
10.19540/j.cnki.cjcmm.20240809.601
- Author:
Jia-Xing WANG
1
;
Qi SHI
2
;
Zuo-Liang ZHANG
1
;
Quan-Sheng WU
3
Author Information
1. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China.
2. College of Pharmacy, Gansu University of Chinese Medicine Lanzhou 730000, China.
3. Clinical College of Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000, China Affiliated Hospital, Gansu University of Chinese Medicine Lanzhou 730000, China.
- Publication Type:English Abstract
- Keywords:
Hedgehog signaling pathway;
angiogenesis;
anti-tumor;
cancer;
traditional Chinese medicine
- MeSH:
Hedgehog Proteins/genetics*;
Humans;
Signal Transduction/drug effects*;
Neoplasms/metabolism*;
Animals;
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2024;49(21):5771-5796
- CountryChina
- Language:Chinese
-
Abstract:
The Hedgehog(Hh) signaling pathway has the functions of improving embryogenesis and maintaining tissue homeostasis. By influencing the tumor microenvironment, intervening in cell apoptosis, and regulating angiogenesis, it is pivotal in the occurrence, progression, and recovery of various tumors. Therefore, targeting and inhibiting the abnormal activation of the Hh pathway has become a potential research strategy for alleviating and treating cancer. Currently, traditional Chinese medicine(TCM) is highly favored for treating cancer and other challenging and severe diseases due to its advantages, such as minimal side effects, high efficacy, lack of dependency, and the ability to address both symptoms and underlying causes. This review aimed to provide a scientific foundation and research ideas for the prevention and treatment of cancer with TCM by summarizing and reviewing the correlation between the Hh pathway and tumors, as well as the feasibility of using TCM to modulate the Hh pathway for anti-tumor effects.
