Scientific connotation in processing of Aconiti Lateralis Radix Praeparata with Glycyrrhizae Radix et Rhizoma based on "interactions between excipients and herbal medicine and component transformation" dynamic processing.
10.19540/j.cnki.cjcmm.20240814.301
- Author:
Yi-Hang ZHAO
1
;
Zhi-Wei WANG
1
;
Lu-Ping YANG
1
;
Xiao-Yu LIN
1
;
Xin-Ru TAN
1
;
Ran XU
1
;
Zhi-Xia WANG
1
;
Liu-Yang ZHANG
1
;
An-Qi XU
1
;
Hai-Min LEI
2
;
Peng-Long WANG
2
;
Xue-Mei HUANG
3
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica Beijing 102488, China.
3. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Traditional Chinese Medicine Processing Technology Inheritance Base of National Administration of Traditional Chinese Medicine Beijing 102488, China Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
Aconiti Lateralis Radix Praeparata;
Glycyrrhizae Radix et Rhizoma;
alkaloids;
glycyrrhizic acid;
interaction
- MeSH:
Drugs, Chinese Herbal/chemistry*;
Aconitum/chemistry*;
Excipients/chemistry*;
Glycyrrhiza/chemistry*;
Tandem Mass Spectrometry;
Chromatography, High Pressure Liquid;
Molecular Dynamics Simulation;
Alkaloids/chemistry*;
Glycyrrhizic Acid/chemistry*
- From:
China Journal of Chinese Materia Medica
2024;49(22):6129-6137
- CountryChina
- Language:Chinese
-
Abstract:
The processing of traditional Chinese medicine(TCM) is a core theory within TCM, embodying deep philosophical, cultural, and natural scientific wisdom. Among the various techniques, the "synergistic processing of medicinal materials and excipients" has garnered significant attention due to its uniqueness. This study explored the impact of the adjuvant Glycyrrhizae Radix et Rhizoma on the dynamic process of component transformation during the processing of Aconiti Lateralis Radix Praeparata using techniques such as acidic dye colorimetry, UPLC-Q-TOF-MS/MS, density functional theory(DFT), and molecular dynamics simulations(MDS). The research revealed that during processing, various alkaloid components in Aconiti Lateralis Radix Praeparata exhibited different weak interactions with glycyrrhizic acid in Glycyrrhizae Radix et Rhizoma, affecting the transformation and content changes of alkaloid components such as aconitine, hypaconitine, and other diester-type alkaloids. This study, based on the dynamic process of "interactions between excipients and herbal medicine and component transformation", elucidated the intrinsic mechanism of processing of Aconiti Lateralis Radix Praeparata with Glycyrrhizae Radix et Rhizoma and provided a reference for understanding the scientific principles underlying the excipient processing of TCM.
